Neuroscience
Anti-NUMBL Antibody (CAB14088)
- SKU:
- CAB14088
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-NUMBL Antibody |
| Antibody SKU: | CAB14088 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPST LQRR TDFQ VKGT VPEM EPPG AGDS DSIN ALCT QISS SFAS AGAP APGP PPAT TGTS AWGE PSVP PAAA FQPG HKRT PSEA ERWL EEVS QVAK AQQQ QQQQ QQQQ QQQQ QQQQ QAAS VAPV PTMP PALQ PFPA PVGP FDAA PAQV AVFL PPPH MQPP FVPA YPGL GYPP MPRV PVVG ITPS QMVA NAFC SAAQ LQPQ PATL LGKA GAFP PPAI PSAP GSQA RPRP NGAP WPPE PAPA PAPE LDPF EAQW AALE GKAT VEKP SNPF SGDL QKTF EIEL |
| Gene ID: | 9253 |
| Uniprot: | Q9Y6R0 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 64kDa |
| Observed MW: |
| Synonyms: | NUMBL, CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23 |
| Background: |
| UniProt Protein Function: | NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 19q13.13-q13.2 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: nervous system development; positive regulation of neurogenesis; axonogenesis; cytokine and chemokine mediated signaling pathway; protein metabolic process; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development |
| UniProt Code: | Q9Y6R0 |
| NCBI GenInfo Identifier: | 14194976 |
| NCBI Gene ID: | 9253 |
| NCBI Accession: | Q9Y6R0.1 |
| UniProt Secondary Accession: | Q9Y6R0,Q7Z4J9, |
| UniProt Related Accession: | Q9Y6R0 |
| Molecular Weight: | 609 |
| NCBI Full Name: | Numb-like protein |
| NCBI Synonym Full Names: | numb homolog (Drosophila)-like |
| NCBI Official Symbol: | NUMBL |
| NCBI Official Synonym Symbols: | NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE |
| NCBI Protein Information: | numb-like protein; numb homolog-like; numb-related protein |
| UniProt Protein Name: | Numb-like protein |
| UniProt Synonym Protein Names: | Numb-related protein; Numb-R |
| Protein Family: | Numb-like protein |
| UniProt Gene Name: | NUMBL |
| UniProt Entry Name: | NUMBL_HUMAN |
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