Anti-NUMB Antibody (CAB9039)

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SKU:
CAB9039
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C14orf41
Synonyms:
S171
Synonyms:
c14_5527
Research Area:
Neuroscience

Description

Product Name:NUMB Rabbit mAb
Product Code:CAB9039
Size:20uL, 50uL, 100uL
Synonyms:C14orf41, S171, c14_5527
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human NUMB
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, NIH/3T3
Immunogen:A synthesized peptide derived from human NUMB
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8650
Uniprot:P49757
Calculated MW:71kDa
Observed MW:66KDa
UniProt Protein Function:NUMB: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: clathrin-coated vesicle; focal adhesion; plasma membrane

Molecular Function:protein binding

Biological Process: lateral ventricle development; neuroblast division in the subventricular zone; positive regulation of cell migration; positive regulation of neurogenesis

NCBI Summary:The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Code:P49757
NCBI GenInfo Identifier:14195675
NCBI Gene ID:8650
NCBI Accession:P49757.2
UniProt Secondary Accession:P49757,Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, B1P2N5 B1P2N6, B1P2N7, B1P2N8, B1P2N9, B4E2B1,
UniProt Related Accession:P49757
Molecular Weight:37,396 Da
NCBI Full Name:Protein numb homolog
NCBI Synonym Full Names:NUMB, endocytic adaptor protein
NCBI Official Symbol:NUMB  
NCBI Official Synonym Symbols:S171; C14orf41; c14_5527  
NCBI Protein Information:protein numb homolog
UniProt Protein Name:Protein numb homolog
UniProt Synonym Protein Names:Protein S171
Protein Family:Numb-like protein
UniProt Gene Name:NUMB  
UniProt Entry Name:NUMB_HUMAN
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