Cell Biology Antibodies 15
Anti-NUF2 Antibody (CAB5026)
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- SKU:
- CAB5026
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NUF2
- Synonyms:
- CDCA1
- Synonyms:
- CT106
- Synonyms:
- NUF2R
- Research Area:
- Cell Biology
Description
| Product Name: | NUF2 Rabbit pAb |
| Product Code: | CAB5026 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NUF2, CDCA1, CT106, NUF2R |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human NUF2 (NP_663735.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human NUF2 (NP_663735.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KLER LDSV PVEE QEEF KQLS DGIQ ELQQ SLNQ DFHQ KTIV LQEG NSQK KSNI SEKT KRLN ELKL SVVS LKEI QESL KTKI VDSP EKLK NYKE KMKD TVQK LKNA RQEV VEKY EIYG DSVD CLPS CQLE VQLY QKKI QDLS DNRE KLAS ILKE SLNL EDQI ESDE SELK KLKT EENS FKRL MIVK KEKL ATAQ FKIN KKHE DVKQ YKRT VIED CNKV QEKR GAVY ERVT TINQ EIQK IKLG IQQL KDAA EREK LKSQ EIFL NLKT ALEK YHDG IEKA AEDS YAKI DEKT AELK RKMF KMST |
| Gene ID: | 83540 |
| Uniprot: | Q9BZD4 |
| Cellular Location: | Chromosome, Nucleus, centromere, kinetochore |
| Calculated MW: | 54kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | NUF2: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Belongs to the NUF2 family. |
| UniProt Protein Details: | Protein type:DNA replication; Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: membrane; nucleus; cytosol; chromosome, pericentric region Molecular Function:protein binding Biological Process: mitosis; cell division; mitotic cell cycle; chromosome segregation |
| NCBI Summary: | This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZD4 |
| NCBI GenInfo Identifier: | 115311829 |
| NCBI Gene ID: | 83540 |
| NCBI Accession: | Q9BZD4.2 |
| UniProt Related Accession: | Q9BZD4 |
| Molecular Weight: | 54kDa |
| NCBI Full Name: | Kinetochore protein Nuf2 |
| NCBI Synonym Full Names: | NUF2 component of NDC80 kinetochore complex |
| NCBI Official Symbol: | NUF2 |
| NCBI Official Synonym Symbols: | CDCA1; CT106; NUF2R |
| NCBI Protein Information: | kinetochore protein Nuf2 |
| UniProt Protein Name: | Kinetochore protein Nuf2 |
| UniProt Synonym Protein Names: | Cell division cycle-associated protein 1 |
| Protein Family: | Kinetochore protein |
| UniProt Gene Name: | NUF2 |
| UniProt Entry Name: | NUF2_HUMAN |
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