Cell Biology Antibodies 15

Anti-NUF2 Antibody (CAB5026)

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SKU:
CAB5026
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NUF2
Synonyms:
CDCA1
Synonyms:
CT106
Synonyms:
NUF2R
Research Area:
Cell Biology

Description

Product Name:NUF2 Rabbit pAb
Product Code:CAB5026
Size:20uL, 50uL, 100uL
Synonyms:NUF2, CDCA1, CT106, NUF2R
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human NUF2 (NP_663735.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human NUF2 (NP_663735.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KLER LDSV PVEE QEEF KQLS DGIQ ELQQ SLNQ DFHQ KTIV LQEG NSQK KSNI SEKT KRLN ELKL SVVS LKEI QESL KTKI VDSP EKLK NYKE KMKD TVQK LKNA RQEV VEKY EIYG DSVD CLPS CQLE VQLY QKKI QDLS DNRE KLAS ILKE SLNL EDQI ESDE SELK KLKT EENS FKRL MIVK KEKL ATAQ FKIN KKHE DVKQ YKRT VIED CNKV QEKR GAVY ERVT TINQ EIQK IKLG IQQL KDAA EREK LKSQ EIFL NLKT ALEK YHDG IEKA AEDS YAKI DEKT AELK RKMF KMST
Gene ID:83540
Uniprot:Q9BZD4
Cellular Location:Chromosome, Nucleus, centromere, kinetochore
Calculated MW:54kDa
Observed MW:Refer to figures
UniProt Protein Function:NUF2: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Belongs to the NUF2 family.
UniProt Protein Details:

Protein type:DNA replication; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: membrane; nucleus; cytosol; chromosome, pericentric region

Molecular Function:protein binding

Biological Process: mitosis; cell division; mitotic cell cycle; chromosome segregation

NCBI Summary:This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZD4
NCBI GenInfo Identifier:115311829
NCBI Gene ID:83540
NCBI Accession:Q9BZD4.2
UniProt Related Accession:Q9BZD4
Molecular Weight:54kDa
NCBI Full Name:Kinetochore protein Nuf2
NCBI Synonym Full Names:NUF2 component of NDC80 kinetochore complex
NCBI Official Symbol:NUF2  
NCBI Official Synonym Symbols:CDCA1; CT106; NUF2R  
NCBI Protein Information:kinetochore protein Nuf2
UniProt Protein Name:Kinetochore protein Nuf2
UniProt Synonym Protein Names:Cell division cycle-associated protein 1
Protein Family:Kinetochore protein
UniProt Gene Name:NUF2  
UniProt Entry Name:NUF2_HUMAN
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