Cell Biology Antibodies 1
Anti-NUDT6 Antibody (CAB0260)
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- SKU:
- CAB0260
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NUDT6 Antibody |
| Antibody SKU: | CAB0260 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human NUDT6 (NP_009014.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Jurkat, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human NUDT6 (NP_009014.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRQP LSWG RWRA MLAR TYGP GPSA GYRW ASGA QGYV RNPP VGAC DLQG ELDR FGGI SVRL ARLD ALDR LDAA AFQK GLQA AVQQ WRSE GRTA VWLH IPIL QSRF IAPA ASLG FCFH HAES DSST LTLW LREG PSRL PGYA SHQV GVAG AVFD ESTR KILV VQDR NKLK NMWK FPGG LSEP EEDI GDTA VREV FEET GIKS EFRS VLSI RQQH TNPG AFGK SDMY IICR LKPY SFTI NFCQ EECL RCEW MDLN DLAK TENT TPIT SRVA RLLL YGYR EGFD KIDL TVEE LPAV YTGL FYKL YHKE LPEN YKTM KGID |
| Gene ID: | 11162 |
| Uniprot: | P53370 |
| Cellular Location: | Cytoplasm, Mitochondrion, Nucleus |
| Calculated MW: | 17kDa/35kDa |
| Observed MW: | 47kDa |
| Synonyms: | NUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1 |
| Background: | This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NUDT6: May contribute to the regulation of cell proliferation. Belongs to the Nudix hydrolase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q26 Cellular Component: mitochondrion; nucleus Molecular Function:growth factor activity; hydrolase activity Biological Process: metabolic process |
| NCBI Summary: | This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P53370 |
| NCBI GenInfo Identifier: | 17380446 |
| NCBI Gene ID: | 11162 |
| NCBI Accession: | P53370.2 |
| UniProt Secondary Accession: | P53370,O95097, Q9UQD9, A8K756, |
| UniProt Related Accession: | P53370 |
| Molecular Weight: | 316 |
| NCBI Full Name: | Nucleoside diphosphate-linked moiety X motif 6 |
| NCBI Synonym Full Names: | nudix (nucleoside diphosphate linked moiety X)-type motif 6 |
| NCBI Official Symbol: | NUDT6 |
| NCBI Official Synonym Symbols: | GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS |
| NCBI Protein Information: | nucleoside diphosphate-linked moiety X motif 6; antisense basic fibroblast growth factor |
| UniProt Protein Name: | Nucleoside diphosphate-linked moiety X motif 6 |
| UniProt Synonym Protein Names: | Antisense basic fibroblast growth factor; Protein GFG |
| Protein Family: | Nudix hydrolase |
| UniProt Gene Name: | NUDT6 |
| UniProt Entry Name: | NUDT6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NUDT6 antibody (CAB0260) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of HeLa cells using NUDT6 antibody (CAB0260). Blue: DAPI for nuclear staining. |
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