Metabolism Antibodies 3

Anti-NUDT18 Antibody (CAB8514)

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SKU:
CAB8514
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-NUDT18 Antibody
Antibody SKU:CAB8514
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human NUDT18 (NP_079091.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human NUDT18 (NP_079091.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASE GLAG ALAS VLAG QGSS VHSC DSAP AGEP PAPV RLRK NVCY VVLA VFLS EQDE VLLI QEAK RECR GSWY LPAG RMEP GETI VEAL QREV KEEA GLHC EPET LLSV EERG PSWV RFVF LARP TGGI LKTS KEAD AESL QAAW YPRT SLPT PLRA HDIL HLVE LAAQ YRQQ ARHP LILP QELP CDLV CQRL VATF TSAQ TVWV LVGT VGMP HLPV TACG LDPM EQRG GMKM AVLR LLQE CLTL HHLV VEIK GLLG LQHL GRDH SDGI CLNV LVTV AFRS PGIQ DEPP KVRG ENFS WWKV MEED LQSQ LLQR LQGS SVVP VNR
Gene ID:79873
Uniprot:Q6ZVK8
Cellular Location:
Calculated MW:24kDa/35kDa
Observed MW:36kDa
Synonyms:NUDT18, MTH3
Background:The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates.
UniProt Protein Function:NUDT18: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. Belongs to the Nudix hydrolase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.6.1.58

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol

Molecular Function:protein binding; magnesium ion binding

Biological Process: GDP catabolic process; nucleobase, nucleoside and nucleotide metabolic process; dGDP catabolic process; dADP catabolic process

NCBI Summary:The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
UniProt Code:Q6ZVK8
NCBI GenInfo Identifier:118026927
NCBI Gene ID:79873
NCBI Accession:NP_079091
UniProt Related Accession:Q6ZVK8
Molecular Weight:
NCBI Full Name:8-oxo-dGDP phosphatase NUDT18
NCBI Synonym Full Names:nudix hydrolase 18
NCBI Official Symbol:NUDT18  
NCBI Official Synonym Symbols:MTH3  
NCBI Protein Information:8-oxo-dGDP phosphatase NUDT18
UniProt Protein Name:8-oxo-dGDP phosphatase NUDT18
UniProt Synonym Protein Names:2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; MutT homolog 3; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18
Protein Family:Nudix hydrolase
UniProt Gene Name:NUDT18  
UniProt Entry Name:NUD18_HUMAN
Anti-NUDT18 Polyclonal Antibody (CAB8514)Western blot analysis of extracts of MCF-7 cells, using NUDT18 antibody (CAB8514) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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