Cell Biology Antibodies 4
Anti-NUDT15 Antibody (CAB14141)
- SKU:
- CAB14141
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-NUDT15 Antibody |
Antibody SKU: | CAB14141 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
Reactivity: | Mouse, Rat |
Positive Samples: | rat spleen |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MTAS AQPR GRRP GVGV GVVV TSCK HPRC VLLG KRKG SVGA GSFQ LPGG HLEF GETW EECA QRET WEEA ALHL KNVH FASV VNSF IEKE NYHY VTIL MKGE VDVT HDSE PKNV EPEK NESW EWVP WEEL PPLD QLFW GLRC LKEQ GYDP FKED LNHL VGYK GNHL |
Gene ID: | 55270 |
Uniprot: | Q9NV35 |
Cellular Location: | |
Calculated MW: | 18kDa |
Observed MW: | 19kDa |
Synonyms: | NUDT15, MTH2, NUDT15D |
Background: | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. |
UniProt Protein Function: | NUDT15: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. Belongs to the Nudix hydrolase family.Protein type: Hydrolase; EC 3.6.1.55Chromosomal Location of Human Ortholog: 13q14.2Cellular Component: cytosolMolecular Function: 8-oxo-7,8-dihydroguanine triphosphatase activity; nucleoside-diphosphatase activityBiological Process: dGTP catabolic process |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] |
UniProt Code: | Q9NV35 |
NCBI GenInfo Identifier: | 68565944 |
NCBI Gene ID: | 55270 |
NCBI Accession: | Q9NV35.1 |
UniProt Secondary Accession: | Q9NV35,Q32Q27, Q6P2C9, A2RUR6 |
UniProt Related Accession: | Q9NV35 |
Molecular Weight: | 18,609 Da |
NCBI Full Name: | Probable 8-oxo-dGTP diphosphatase NUDT15 |
NCBI Synonym Full Names: | nudix hydrolase 15 |
NCBI Official Symbol: | NUDT15 |
NCBI Official Synonym Symbols: | MTH2; NUDT15D |
NCBI Protein Information: | probable 8-oxo-dGTP diphosphatase NUDT15 |
UniProt Protein Name: | Probable 8-oxo-dGTP diphosphatase NUDT15 |
UniProt Synonym Protein Names: | 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15 |
Protein Family: | Nudix hydrolase |
UniProt Gene Name: | NUDT15 |
UniProt Entry Name: | NUD15_HUMAN |
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