Cell Cycle Antibodies 1
Anti-NUDC Antibody (CAB6678)
- SKU:
- CAB6678
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-NUDC Antibody |
| Antibody SKU: | CAB6678 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human NUDC (NP_006591.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human NUDC (NP_006591.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGGE QEEE RFDG MLLA MAQQ HEGG VQEL VNTF FSFL RRKT DFFI GGEE GMAE KLIT QTFS HHNQ LAQK TRRE KRAR QEAE RREK AERA ARLA KEAK SETS GPQI KELT DEEA ERLQ LEID QKKD AENH EAQL KNGS LDSP GKQD TEED EEED EKDK GKLK PNLG NGAD LPNY RWTQ TLSE LDLA VPFC VNFR LKGK DMVV DIQR RHLR VGLK GQPA IIDG ELYN EVKV EESS WLIE DGKV VTVH LEKI NKME WWSR LVSS DPEI NTKK INPE NSKL SDLD SETR SMVE KMMY DQRQ KSMG LPTS DEQK KQEI LKKF MDQH PEMD FSKA KFN |
| Gene ID: | 10726 |
| Uniprot: | Q9Y266 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton |
| Calculated MW: | 38kDa |
| Observed MW: | 45kDa |
| Synonyms: | NUDC, HNUDC, MNUDC, NPD011 |
| Background: | This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. |
| UniProt Protein Function: | NUDC: a cytoskeletal protein that is a component of the dynactin complex. The cytoplasmic dynein/dynactin complex, a minus-end-directed motor, powers various) aspects of mitosis, including establishment of bipolarity, organization of spindle poles, alignment and segregation of chromosomes, as well as regulation of microtubule dynamics. Phosphorylation by PLK1 may play a critical role in cytokinesis. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:protein binding Biological Process: cell proliferation; multicellular organismal development; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9Y266 |
| NCBI GenInfo Identifier: | 62287138 |
| NCBI Gene ID: | 10726 |
| NCBI Accession: | Q9Y266.1 |
| UniProt Secondary Accession: | Q9Y266,Q5QP31, Q5QP35, Q9H0N2, Q9Y2B6, |
| UniProt Related Accession: | Q9Y266 |
| Molecular Weight: | 38,243 Da |
| NCBI Full Name: | Nuclear migration protein nudC |
| NCBI Synonym Full Names: | nuclear distribution C, dynein complex regulator |
| NCBI Official Symbol: | NUDC |
| NCBI Official Synonym Symbols: | HNUDC; MNUDC; NPD011 |
| NCBI Protein Information: | nuclear migration protein nudC |
| UniProt Protein Name: | Nuclear migration protein nudC |
| UniProt Synonym Protein Names: | Nuclear distribution protein C homolog |
| Protein Family: | NADH pyrophosphatase |
| UniProt Gene Name: | NUDC |
| UniProt Entry Name: | NUDC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NUDC antibody (CAB6678) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using NUDC antibody (CAB6678) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat stomach using NUDC antibody (CAB6678) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NUDC antibody (CAB6678) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using NUDC antibody (CAB6678). |
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