Cell Biology Antibodies 8
Anti-NTSR1 Antibody (CAB3054)
- SKU:
- CAB3054
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NTSR1 Antibody |
| Antibody SKU: | CAB3054 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human NTSR1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, 22Rv1, SW620, HT-29, Mouse brain |
| Immunogen: | A synthetic peptide of human NTSR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4923 |
| Uniprot: | P30989 |
| Cellular Location: | Cell membrane, Membrane raft, Multi-pass membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 65kDa |
| Synonyms: | NTSR1, NTR |
| Background: | Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. |
| UniProt Protein Function: | NTSR1: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 20q13 Cellular Component: cell surface; dendritic shaft; dendritic spine; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; internal side of plasma membrane; lipid raft; mitochondrion; perikaryon; plasma membrane; terminal button Molecular Function:G-protein coupled receptor activity; neurotensin receptor activity, G-protein coupled; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding Biological Process: adult locomotory behavior; detection of temperature stimulus involved in sensory perception of pain; G-protein coupled receptor protein signaling pathway; learning; negative regulation of apoptosis; negative regulation of release of sequestered calcium ion into cytosol; negative regulation of systemic arterial blood pressure; neuropeptide signaling pathway; positive regulation of apoptosis; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of release of sequestered calcium ion into cytosol; regulation of respiratory gaseous exchange; regulation of sensory perception of pain; response to lipid; synaptic transmission; thermoregulation |
| NCBI Summary: | Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30989 |
| NCBI GenInfo Identifier: | 62297312 |
| NCBI Gene ID: | 4923 |
| NCBI Accession: | P30989.2 |
| UniProt Secondary Accession: | P30989,Q9H4H1, Q9H4T5, |
| UniProt Related Accession: | P30989 |
| Molecular Weight: | 46,259 Da |
| NCBI Full Name: | Neurotensin receptor type 1 |
| NCBI Synonym Full Names: | neurotensin receptor 1 (high affinity) |
| NCBI Official Symbol: | NTSR1 |
| NCBI Official Synonym Symbols: | NTR |
| NCBI Protein Information: | neurotensin receptor type 1 |
| UniProt Protein Name: | Neurotensin receptor type 1 |
| UniProt Synonym Protein Names: | High-affinity levocabastine-insensitive neurotensin receptor; NTRH |
| Protein Family: | Neurotensin receptor |
| UniProt Gene Name: | NTSR1 |
| UniProt Entry Name: | NTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NTSR1 antibody (CAB3054) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
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