Cell Biology Antibodies 8

Anti-NTF4 Antibody (CAB3180)

(No reviews yet) Write a Review
SKU:
CAB3180
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NTF4 Antibody
Antibody SKU:CAB3180
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human NTF4
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2, MCF7, Mouse brain
Immunogen:Recombinant protein of human NTF4
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4909
Uniprot:P34130
Cellular Location:Secreted
Calculated MW:22kDa
Observed MW:32kDa
Synonyms:NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5
Background:This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
UniProt Protein Function:NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family.
UniProt Protein Details:

Protein type:Cytokine; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: endoplasmic reticulum lumen; cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function:neurotrophin p75 receptor binding; growth factor activity

Biological Process: mechanoreceptor differentiation; epidermis development; cell-cell signaling; long-term memory; regulation of neuron differentiation; adult locomotory behavior; sensory organ boundary specification; ganglion mother cell fate determination; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis

Disease: Glaucoma 1, Open Angle, O

NCBI Summary:This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
UniProt Code:P34130
NCBI GenInfo Identifier:462741
NCBI Gene ID:4909
NCBI Accession:P34130.1
UniProt Secondary Accession:P34130,Q6FH56,
UniProt Related Accession:P34130,AAB20549
Molecular Weight:210
NCBI Full Name:Neurotrophin-4
NCBI Synonym Full Names:neurotrophin 4
NCBI Official Symbol:NTF4  
NCBI Official Synonym Symbols:NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5  
NCBI Protein Information:neurotrophin-4; neurotrophin-5; neutrophic factor 4; neurotrophic factor 4; neurotrophic factor 5; neurotrophin 5 (neurotrophin 4/5)
UniProt Protein Name:Neurotrophin-4
UniProt Synonym Protein Names:Neurotrophin-5; NT-5; Neutrophic factor 4
Protein Family:Neurotrophin
UniProt Gene Name:NTF4  
UniProt Entry Name:NTF4_HUMAN
Anti-NTF4 Antibody (CAB3180)Western blot analysis of extracts of various cell lines, using NTF4 antibody (CAB3180) at 1:300 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021).
View AllClose

0 Reviews

View AllClose

Related Products