Cell Biology Antibodies 9

Anti-NSMF Antibody (CAB4603)

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CAB4603

Description

Product Name:NSMF Rabbit pAb
Product Code:CAB4603
Size:20uL, 50uL, 100uL
Synonyms:NSMF, HH9, NELF
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 226-505 of human NSMF (NP_001124443.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:LO2, HT-29, 293T, BT-474, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 226-505 of human NSMF (NP_001124443.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FQTA TTTM QANF RKHL RMVG SRRV KAQT FAER RERS FSRS WSDP TPMK ADTS HDSR DSSD LQSS HCTL DEAF EDLD WDTE KGLE AVAC DTEG FVPP KVML ISSK VPKA EYIP TIIR RDDP SIIP ILYD HEHA TFED ILEE IERK LNVY HKGA KIWK MLIF CQGG PGHL YLLK NKVA TFAK VEKE EDMI HFWK RLSR LMSK VNPE PNVI HIMG CYIL GNPN GEKL FQNL RTLM TPYR VTFE SPLE LSAQ GKQM IETY FDFR LYRL WKSR QHSK LLDF DDVL
Gene ID:26012
Uniprot:Q6X4W1
Cellular Location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Nucleus envelope, Nucleus matrix, Nucleus membrane, Peripheral membrane protein, cell cortex, cytoskeleton, dendrite, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome
Calculated MW:44kDa/56kDa/57kDa/59kDa/60kDa
Observed MW:70kDa
UniProt Protein Function:NSMF: Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons. Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cortical cytoskeleton; nuclear membrane; neuron projection; nuclear matrix; postsynaptic density; dendrite; nuclear envelope; perikaryon; nucleoplasm; postsynaptic membrane; membrane; cytoplasm; synapse; nucleus; cell junction

Molecular Function:calcium-dependent protein binding

Biological Process: regulation of dendrite morphogenesis; regulation of neuron apoptosis; positive regulation of protein amino acid dephosphorylation; regulation of neuronal synaptic plasticity

Disease: Hypogonadotropic Hypogonadism 9 With Or Without Anosmia

NCBI Summary:The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
UniProt Code:Q6X4W1
NCBI GenInfo Identifier:71152011
NCBI Gene ID:26012
NCBI Accession:Q6X4W1.1
UniProt Secondary Accession:Q6X4W1,Q2TB96, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1 Q9NPM4, Q9NPP3, Q9NPS3,
UniProt Related Accession:Q6X4W1
Molecular Weight:530
NCBI Full Name:NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Synonym Full Names:NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Official Symbol:NSMF  
NCBI Official Synonym Symbols:HH9; NELF  
NCBI Protein Information:NMDA receptor synaptonuclear signaling and neuronal migration factor; nasal embryonic LHRH factor; nasal embryonic luteinizing hormone-releasing hormone factor
UniProt Protein Name:NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Synonym Protein Names:Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Protein Family:NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Gene Name:NSMF  
UniProt Entry Name:NSMF_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NSMF
Synonyms:
HH9
Synonyms:
NELF
Research Area:
Cell Biology
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