Cell Biology Antibodies 6
Anti-NSMAF Antibody (CAB15742)
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- SKU:
- CAB15742
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NSMAF Antibody |
| Antibody SKU: | CAB15742 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAFI RKKQ QEQQ LQLY SKER FSLL LLNL EEYY FEQH RANH ILHK GSHH ERKI RGSL KICS KSVI FEPD SISQ PIIK IPLR DCIK IGKH GENG ANRH FTKA KSGG ISLI FSQV YFIK EHNV VAPY KIER GKME YVFE LDVP GKVE DVVE TLLQ LHRA SCLD KLGD QTAM ITAI LQSR LART SFDK NRFQ NISE KLHM ECKA EMVT PLVT NPGH VCIT DTNL YFQP LNGY PKPV VQIT LQDV RRIY KRRH GLMP LGLE VFCT EDDL CSDI YLKF YEPQ DRDD LYFY IATY LEHH VAEH TAES |
| Gene ID: | 8439 |
| Uniprot: | Q92636 |
| Cellular Location: | |
| Calculated MW: | 104kDa/107kDa |
| Observed MW: | 110kDa |
| Synonyms: | NSMAF, FAN, GRAMD5 |
| Background: | This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. |
| NCBI Summary: | This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q92636 |
| NCBI GenInfo Identifier: | 209572614 |
| NCBI Gene ID: | 8439 |
| NCBI Accession: | Q92636.2 |
| UniProt Secondary Accession: | Q92636,Q8IW26, B4DFB0, E9PCH0, |
| UniProt Related Accession: | Q92636 |
| Molecular Weight: | 107,314 Da |
| NCBI Full Name: | Protein FAN |
| NCBI Synonym Full Names: | neutral sphingomyelinase activation associated factor |
| NCBI Official Symbol: | NSMAF |
| NCBI Official Synonym Symbols: | FAN; GRAMD5 |
| NCBI Protein Information: | protein FAN |
| UniProt Protein Name: | Protein FAN |
| UniProt Synonym Protein Names: | Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation |
| Protein Family: | Protein |
| UniProt Gene Name: | NSMAF |
| UniProt Entry Name: | FAN_HUMAN |
 | Western blot analysis of extracts of mouse brain, using NSMAF antibody (CAB15742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
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