Cell Biology Antibodies 6

Anti-NSMAF Antibody (CAB15742)

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SKU:
CAB15742
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NSMAF Antibody
Antibody SKU:CAB15742
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NSMAF (NP_003571.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAFI RKKQ QEQQ LQLY SKER FSLL LLNL EEYY FEQH RANH ILHK GSHH ERKI RGSL KICS KSVI FEPD SISQ PIIK IPLR DCIK IGKH GENG ANRH FTKA KSGG ISLI FSQV YFIK EHNV VAPY KIER GKME YVFE LDVP GKVE DVVE TLLQ LHRA SCLD KLGD QTAM ITAI LQSR LART SFDK NRFQ NISE KLHM ECKA EMVT PLVT NPGH VCIT DTNL YFQP LNGY PKPV VQIT LQDV RRIY KRRH GLMP LGLE VFCT EDDL CSDI YLKF YEPQ DRDD LYFY IATY LEHH VAEH TAES
Gene ID:8439
Uniprot:Q92636
Cellular Location:
Calculated MW:104kDa/107kDa
Observed MW:110kDa
Synonyms:NSMAF, FAN, GRAMD5
Background:This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
NCBI Summary:This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
UniProt Code:Q92636
NCBI GenInfo Identifier:209572614
NCBI Gene ID:8439
NCBI Accession:Q92636.2
UniProt Secondary Accession:Q92636,Q8IW26, B4DFB0, E9PCH0,
UniProt Related Accession:Q92636
Molecular Weight:107,314 Da
NCBI Full Name:Protein FAN
NCBI Synonym Full Names:neutral sphingomyelinase activation associated factor
NCBI Official Symbol:NSMAF  
NCBI Official Synonym Symbols:FAN; GRAMD5  
NCBI Protein Information:protein FAN
UniProt Protein Name:Protein FAN
UniProt Synonym Protein Names:Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation
Protein Family:Protein
UniProt Gene Name:NSMAF  
UniProt Entry Name:FAN_HUMAN
Anti-NSMAF Antibody (CAB15742)Western blot analysis of extracts of mouse brain, using NSMAF antibody (CAB15742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
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