Cell Cycle Antibodies 2
Anti-NSL1 Antibody (CAB7089)
- SKU:
- CAB7089
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-NSL1 Antibody |
| Antibody SKU: | CAB7089 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human NSL1 (NP_056286.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human NSL1 (NP_056286.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGS PELV VLDP PWDK ELAA GTES QALV SATP REDF RVRC TSKR AVTE MLQL CGRF VQKL GDAL PEEI REPA LRDA QWTF ESAV QENI SING QAWQ EASD NCFM DSDI KVLE DQFD EIIV DIAT KRKQ YPRK ILEC VIKT IKAK QEIL KQYH PVVH PLDL KYDP DPAP HMEN LKCR GETV AKEI SEAM KSLP ALIE QGEG FSQV LRMQ PVIH LQRI HQEV FSSC HRKP DAKP ENFI TQIE TTPT ETAS RKTS DMVL KRKQ TKDC PQRK WYPL RPKK INLD T |
| Gene ID: | 25936 |
| Uniprot: | Q96IY1 |
| Cellular Location: | Chromosome, Nucleus, centromere, kinetochore |
| Calculated MW: | 24kDa/32kDa |
| Observed MW: | Refer to figures |
| Synonyms: | NSL1, C1orf48, DC8, MIS14 |
| Background: | This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. |
| UniProt Protein Function: | NSL1: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytosol; nucleus; MIS12/MIND type complex Molecular Function:protein binding Biological Process: mitosis; cell division; mitotic cell cycle; chromosome segregation |
| NCBI Summary: | This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q96IY1 |
| NCBI GenInfo Identifier: | 147744577 |
| NCBI Gene ID: | 25936 |
| NCBI Accession: | Q96IY1.3 |
| UniProt Secondary Accession: | Q96IY1,Q5SY75, Q9H2M5, Q9NRN8, Q9Y415, E7ETD5, |
| UniProt Related Accession: | Q96IY1 |
| Molecular Weight: | 281 |
| NCBI Full Name: | Kinetochore-associated protein NSL1 homolog |
| NCBI Synonym Full Names: | NSL1, MIS12 kinetochore complex component |
| NCBI Official Symbol: | NSL1 |
| NCBI Official Synonym Symbols: | DC8; MIS14; C1orf48 |
| NCBI Protein Information: | kinetochore-associated protein NSL1 homolog; NSL1, MIND kinetochore complex component, homolog |
| UniProt Protein Name: | Kinetochore-associated protein NSL1 homolog |
| Protein Family: | Kinetochore-associated protein |
| UniProt Gene Name: | NSL1 |
| UniProt Entry Name: | NSL1_HUMAN |
 | Immunofluorescence analysis of A549 cells using NSL1 antibody (CAB7089). |
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