Cell Biology Antibodies 14
Anti-NRXN2 Antibody (CAB17050)
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- SKU:
- CAB17050
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NRXN2 Antibody |
| Antibody SKU: | CAB17050 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human NRXN2 (NP_055895.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human NRXN2 (NP_055895.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VTSA PGFP HLPT ANPT GPGE RGPP GAVE VIRE SSST TGMV VGIV AAAA LCIL ILLY AMYK YRNR DEGS YQVD QSRN YISN SAQS NGAV VKEK APAA PKTP SKAK KNKD KEYY V |
| Gene ID: | 9379 |
| Uniprot: | Q9P2S2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NRXN2 |
| Background: | This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992). |
| UniProt Protein Function: | NRXN2 iso3: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to membrane Molecular Function:metal ion binding; calcium channel regulator activity; cell adhesion molecule binding Biological Process: synaptic transmission; synaptogenesis; adult behavior; neurotransmitter secretion; neuron adhesion; social behavior; vocal learning |
| NCBI Summary: | This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q9P2S2 |
| NCBI GenInfo Identifier: | 152012540 |
| NCBI Gene ID: | 9379 |
| NCBI Accession: | AAI50276.1 |
| UniProt Related Accession: | P58401,Q9P2S2 |
| Molecular Weight: | 70,927 Da |
| NCBI Full Name: | Neurexin 2 |
| NCBI Synonym Full Names: | neurexin 2 |
| NCBI Official Symbol: | NRXN2 |
| NCBI Protein Information: | neurexin-2-beta; neurexin II |
| UniProt Protein Name: | Neurexin-2-beta |
| UniProt Synonym Protein Names: | Neurexin II-beta |
| Protein Family: | Neurexin |
| UniProt Gene Name: | NRXN2 |
| UniProt Entry Name: | NRX2B_HUMAN |
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