Epigenetics & Nuclear Signaling Antibodies 3
Anti-NRF1 Antibody (CAB14190)
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- SKU:
- CAB14190
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NRF1 Antibody |
| Antibody SKU: | CAB14190 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NRF1 (NP_001035199.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NRF1 (NP_001035199.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEH GVTQ TEHM ATIE AHAV AQQV QQVH VATY TEHS MLSA DEDS PSSP EDTS YDDS DILN STAA DEVT AHLA AAGP VGMA AAAA VATG KKRK RPHV FESN PSIR KRQQ TRLL RKLR ATLD EYTT RVGQ QAIV LCIS PSKP NPVF KVFG AAPL ENVV RKYK SMIL EDLE SALA EHAP APQE VNSE LPPL TIDG IPVS VDKM TQAQ LRAF IPEM LKYS TGRG KPGW GKES CKPI WWPE DIPW ANVR SDVR TEEQ KQRV SWTQ ALRT IVKN CYKQ HGRE DLLY AFED QQTQ TQAT ATHS IAHL |
| Gene ID: | 4899 |
| Uniprot: | Q16656 |
| Cellular Location: | Nucleus |
| Calculated MW: | 36kDa/46kDa/53kDa/55kDa |
| Observed MW: | Refer to figures |
| Synonyms: | NRF1, ALPHA-PAL |
| Background: | This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. |
| UniProt Protein Function: | NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 7q32 Cellular Component: nucleoplasm; cytoplasm Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; response to folic acid; organelle organization and biogenesis; response to hypoxia; response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus |
| NCBI Summary: | This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014] |
| UniProt Code: | Q16656 |
| NCBI GenInfo Identifier: | 12643732 |
| NCBI Gene ID: | 4899 |
| NCBI Accession: | Q16656.1 |
| UniProt Secondary Accession: | Q16656,Q15305, Q96AN2, A8K4C6, B4DDV6, |
| UniProt Related Accession: | Q16656 |
| Molecular Weight: | 55,674 Da |
| NCBI Full Name: | Nuclear respiratory factor 1 |
| NCBI Synonym Full Names: | nuclear respiratory factor 1 |
| NCBI Official Symbol: | NRF1 |
| NCBI Official Synonym Symbols: | ALPHA-PAL |
| NCBI Protein Information: | nuclear respiratory factor 1; alpha palindromic-binding protein |
| UniProt Protein Name: | Nuclear respiratory factor 1 |
| UniProt Synonym Protein Names: | Alpha palindromic-binding protein; Alpha-pal |
| Protein Family: | Nuclear respiratory factor |
| UniProt Gene Name: | NRF1 |
| UniProt Entry Name: | NRF1_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver damage using NRF1 Antibody (CAB14190) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NRF1 Antibody (CAB14190) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using NRF1 Antibody (CAB14190) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of NIH/3T3 cells using NRF1 antibody (CAB14190) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of PC12 cells using NRF1 antibody (CAB14190) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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