Anti-NRAS Antibody (CAB7566)

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SKU:
CAB7566
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NRAS
Synonyms:
ALPS4
Synonyms:
CMNS
Synonyms:
N-ras
Synonyms:
NCMS
Synonyms:
NRAS1
Synonyms:
NS6
Research Area:
Cell Biology

Description

Product Name:NRAS Rabbit pAb
Product Code:CAB7566
Size:20uL, 50uL, 100uL
Synonyms:NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human NRAS (NP_002515.1).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Jurkat, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human NRAS (NP_002515.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTEY KLVV VGAG GVGK SALT IQLI QNHF VDEY DPTI EDSY RKQV VIDG ETCL LDIL DTAG QEEY SAMR DQYM RTGE GFLC VFAI NNSK SFAD INLY REQI KRVK DSDD VPMV LVGN KCDL PTRT VDTK QAHE LAKS YGIP FIET SAKT RQGV EDAF YTLV REIR QYRM KKLN SSDD GTQG CMGL PCVV M
Gene ID:4893
Uniprot:P01111
Cellular Location:Cell membrane, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor
Calculated MW:21kDa
Observed MW:21KDa
UniProt Protein Function:NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: Golgi apparatus; membrane; plasma membrane

Molecular Function:protein complex binding

Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway

Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular

NCBI Summary:This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
UniProt Code:P01111
NCBI GenInfo Identifier:131883
NCBI Gene ID:4893
NCBI Accession:P01111.1
UniProt Secondary Accession:P01111,Q14971, Q15104, Q15282,
UniProt Related Accession:P01111
Molecular Weight:21,229 Da
NCBI Full Name:GTPase NRas
NCBI Synonym Full Names:neuroblastoma RAS viral oncogene homolog
NCBI Official Symbol:NRAS  
NCBI Official Synonym Symbols:NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1  
NCBI Protein Information:GTPase NRas
UniProt Protein Name:GTPase NRas
UniProt Synonym Protein Names:Transforming protein N-Ras
Protein Family:GTPase
UniProt Gene Name:NRAS  
UniProt Entry Name:RASN_HUMAN
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