Epigenetics & Nuclear Signaling Antibodies 5
Anti-NR5A2 Antibody (CAB16854)
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- SKU:
- CAB16854
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NR5A2 Antibody |
| Antibody SKU: | CAB16854 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human NR5A2 (NP_003813.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human NR5A2 (NP_003813.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSN SDTG DLQE SLKH GLTP IVSQ FKMV NYSY DEDL EELC PVCG DKVS GYHY GLLT CESC KGFF KRTV QNNK RYTC IENQ NCQI DKTQ RKRC PYCR FQKC LSVG MKLE AVRA DRMR GGRN KFGP MYKR DRAL KQQK KALI |
| Gene ID: | 2494 |
| Uniprot: | O00482 |
| Cellular Location: | |
| Calculated MW: | 42kDa/53kDa/56kDa/61kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - NR5A2 Polyclonal Antibody (CAB16854) |
| Synonyms: | NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2 |
| Background: | The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. |
| UniProt Protein Function: | NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor; Transcription factor Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; phospholipid binding; steroid hormone receptor activity; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of viral genome replication; intracellular receptor-mediated signaling pathway; bile acid metabolic process; positive regulation of transcription, DNA-dependent; endocrine pancreas development; regulation of cell proliferation; cholesterol homeostasis; embryonic development; homeostatic process; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression |
| UniProt Code: | O00482 |
| NCBI GenInfo Identifier: | 7676156 |
| NCBI Gene ID: | 2494 |
| NCBI Accession: | O00482.2 |
| UniProt Secondary Accession: | O00482,O95642, Q147U3, B4E2P3, |
| UniProt Related Accession: | O00482 |
| Molecular Weight: | 541 |
| NCBI Full Name: | Nuclear receptor subfamily 5 group A member 2 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 5, group A, member 2 |
| NCBI Official Symbol: | NR5A2 |
| NCBI Official Synonym Symbols: | B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta |
| NCBI Protein Information: | nuclear receptor subfamily 5 group A member 2; nuclear receptor NR5A2; liver receptor homolog 1; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor hB1F-3; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus |
| UniProt Protein Name: | Nuclear receptor subfamily 5 group A member 2 |
| UniProt Synonym Protein Names: | Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; LRH-1 |
| Protein Family: | Nuclear receptor subfamily |
| UniProt Gene Name: | NR5A2 |
| UniProt Entry Name: | NR5A2_HUMAN |
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