Epigenetics & Nuclear Signaling Antibodies 3

Anti-NR4A2 Antibody (CAB17318)

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SKU:
CAB17318
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NR4A2 Antibody
Antibody SKU:CAB17318
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human NR4A2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic Peptide of human NR4A2.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4929
Uniprot:P43354
Cellular Location:Cytoplasm, Nucleus
Calculated MW:59kDa/66kDa
Observed MW:Refer to figures
Synonyms:NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR
Background:This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
UniProt Protein Function:Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
NCBI Summary:This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P43354
NCBI GenInfo Identifier:187423888
NCBI Gene ID:4929
NCBI Accession:NP_006177.1
UniProt Secondary Accession:P43354,Q16311, Q53RZ2, Q6NXU0,
UniProt Related Accession:P43354
Molecular Weight:59,809 Da
NCBI Full Name:Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA
NCBI Synonym Full Names:nuclear receptor subfamily 4, group A, member 2
NCBI Official Symbol:NR4A2  
NCBI Official Synonym Symbols:NOT; RNR1; HZF-3; NURR1; TINUR  
NCBI Protein Information:nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1
UniProt Protein Name:Nuclear receptor subfamily 4 group A member 2
UniProt Synonym Protein Names:Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
Protein Family:Nuclear receptor subfamily
UniProt Gene Name:NR4A2  
UniProt Entry Name:NR4A2_HUMAN
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