Epigenetics & Nuclear Signaling Antibodies 2

Anti-NR1H2 Antibody (CAB16291)

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SKU:
CAB16291
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NR1H2 Antibody
Antibody SKU:CAB16291
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human NR1H2 (NP_009052.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-431, SH-SY5Y, Mouse liver, Mouse brain, Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human NR1H2 (NP_009052.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KEAG MREQ CVLS EEQI RKKK IRKQ QQQE SQSQ SQSP VGPQ GSSS SASG PGAS PGGS EAGS QGSG EGEG VQLT AAQE LMIQ QLVA AQLQ CNKR SFSD QPKV T
Gene ID:7376
Uniprot:P55055
Cellular Location:Nucleus
Calculated MW:39kDa/50kDa
Observed MW:51kDa
Synonyms:NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR
Background:
UniProt Protein Function:LXR-beta: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Forms a heterodimer with RXR. Ubiquitous. Belongs to the nuclear hormone receptor family. NR1 subfamily.
UniProt Protein Details:

Protein type:Nuclear receptor

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:apolipoprotein A-I receptor binding; ATPase binding; DNA binding; protein binding

Biological Process: negative regulation of lipid transport; negative regulation of pinocytosis; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter

NCBI Summary:The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
UniProt Code:P55055
NCBI GenInfo Identifier:296439251
NCBI Gene ID:7376
NCBI Accession:P55055.2
UniProt Secondary Accession:P55055,Q12970, Q5I0Y1, A8K490, B4DNM6, E7EWA6,
UniProt Related Accession:P55055
Molecular Weight:39,920 Da
NCBI Full Name:Oxysterols receptor LXR-beta
NCBI Synonym Full Names:nuclear receptor subfamily 1 group H member 2
NCBI Official Symbol:NR1H2  
NCBI Official Synonym Symbols:NER; UNR; LXRB; LXR-b; NER-I; RIP15  
NCBI Protein Information:oxysterols receptor LXR-beta
UniProt Protein Name:Oxysterols receptor LXR-beta
UniProt Synonym Protein Names:Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
Protein Family:Oxysterols receptor
UniProt Gene Name:NR1H2  
UniProt Entry Name:NR1H2_HUMAN
Anti-NR1H2 Antibody (CAB16291)Western blot analysis of extracts of various cell lines, using NR1H2 antibody (CAB16291) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
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