Cell Biology Antibodies 2
Anti-NQO2 Antibody (CAB11742)
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- SKU:
- CAB11742
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NQO2 Antibody |
| Antibody SKU: | CAB11742 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-1-231 of human NQO2 (NP_000895.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, 293T, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-1-231 of human NQO2 (NP_000895.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGK KVLI VYAH QEPK SFNG SLKN VAVD ELSR QGCT VTVS DLYA MNLE PRAT DKDI TGTL SNPE VFNY GVET HEAY KQRS LASD ITDE QKKV READ LVIF QFPL YWFS VPAI LKGW MDRV LCQG FAFD IPGF YDSG LLQG KLAL LSVT TGGT AEMY TKTG VNGD SRYF LWPL QHGT LHFC GFKV LAPQ ISFA PEIA SEEE RKGM VAAW SQRL QTIW KEEP IPCT AHWH FGQ |
| Gene ID: | 4835 |
| Uniprot: | P16083 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 25kDa |
| Observed MW: | 26kDa |
| Synonyms: | NQO2, DHQV, DIA6, NMOR2, QR2 |
| Background: | This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NQO2: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Belongs to the NAD(P)H dehydrogenase (quinone) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.10.99.2 Chromosomal Location of Human Ortholog: 6p25.2 Cellular Component: nucleoplasm; cytoplasm Molecular Function:electron carrier activity; dihydronicotinamide riboside quinone reductase activity; NADPH dehydrogenase (quinone) activity; metal ion binding Biological Process: memory Disease: Breast Cancer |
| NCBI Summary: | This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | P16083 |
| NCBI GenInfo Identifier: | 317373581 |
| NCBI Gene ID: | 4835 |
| NCBI Accession: | P16083.5 |
| UniProt Secondary Accession: | P16083,Q9JI75, |
| UniProt Related Accession: | P16083 |
| Molecular Weight: | 231 |
| NCBI Full Name: | Ribosyldihydronicotinamide dehydrogenase |
| NCBI Synonym Full Names: | NAD(P)H dehydrogenase, quinone 2 |
| NCBI Official Symbol: | NQO2 |
| NCBI Official Synonym Symbols: | QR2; DHQV; DIA6; NMOR2 |
| NCBI Protein Information: | ribosyldihydronicotinamide dehydrogenase [quinone]; ribosyldihydronicotinamide dehydrogenase [quinone]; quinone reductase 2; NRH:quinone oxidoreductase 2; NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2 |
| UniProt Protein Name: | Ribosyldihydronicotinamide dehydrogenase [quinone] |
| UniProt Synonym Protein Names: | NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2 |
| Protein Family: | NADH-quinone oxidoreductase |
| UniProt Gene Name: | NQO2 |
| UniProt Entry Name: | NQO2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NQO2 antibody (CAB11742) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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