Cell Biology Antibodies 8

Anti-NPY1R Antibody (CAB3116)

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SKU:
CAB3116
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPY1R Antibody
Antibody SKU:CAB3116
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human NPY1R
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse fetal brain
Immunogen:A synthetic peptide of human NPY1R
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4886
Uniprot:P25929
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:44kDa
Observed MW:44kDa
Synonyms:NPY1R, NPY1-R, NPYR
Background:This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity.
UniProt Protein Function:NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 4q31.3-q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain

NCBI Summary:This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
UniProt Code:P25929
NCBI GenInfo Identifier:128997
NCBI Gene ID:4886
NCBI Accession:P25929.1
UniProt Secondary Accession:P25929,B2R6H5,
UniProt Related Accession:P25929
Molecular Weight:384
NCBI Full Name:Neuropeptide Y receptor type 1
NCBI Synonym Full Names:neuropeptide Y receptor Y1
NCBI Official Symbol:NPY1R  
NCBI Official Synonym Symbols:NPYR; NPY1-R  
NCBI Protein Information:neuropeptide Y receptor type 1
UniProt Protein Name:Neuropeptide Y receptor type 1
Protein Family:Neuropeptide Y receptor
UniProt Gene Name:NPY1R  
UniProt Entry Name:NPY1R_HUMAN
Anti-NPY1R Antibody (CAB3116)Western blot analysis of extracts of mouse fetal brain, using NPY1R antibody (CAB3116). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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