Cell Biology Antibodies 14
Anti-NPY1R Antibody (CAB16933)
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- SKU:
- CAB16933
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NPY1R Antibody |
| Antibody SKU: | CAB16933 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human NPY1R. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human NPY1R. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4886 |
| Uniprot: | P25929 |
| Cellular Location: | |
| Calculated MW: | 44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | NPY1R, NPY1-R, NPYR |
| Background: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. |
| UniProt Protein Function: | NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 4q31.3-q32 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain |
| NCBI Summary: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P25929 |
| NCBI GenInfo Identifier: | 128997 |
| NCBI Gene ID: | 4886 |
| NCBI Accession: | P25929.1 |
| UniProt Secondary Accession: | P25929,B2R6H5, |
| UniProt Related Accession: | P25929 |
| Molecular Weight: | 384 |
| NCBI Full Name: | Neuropeptide Y receptor type 1 |
| NCBI Synonym Full Names: | neuropeptide Y receptor Y1 |
| NCBI Official Symbol: | NPY1R |
| NCBI Official Synonym Symbols: | NPYR; NPY1-R |
| NCBI Protein Information: | neuropeptide Y receptor type 1 |
| UniProt Protein Name: | Neuropeptide Y receptor type 1 |
| Protein Family: | Neuropeptide Y receptor |
| UniProt Gene Name: | NPY1R |
| UniProt Entry Name: | NPY1R_HUMAN |
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