Cell Biology Antibodies 2

Anti-NPTX2 Antibody (CAB12031)

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SKU:
CAB12031
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPTX2 Antibody
Antibody SKU:CAB12031
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human NPTX2 (NP_002514.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SH-SY5Y, BxPC-3, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human NPTX2 (NP_002514.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KLAR CEGL AGGK ARGA GATG KDTM GDLP RDPG HVVE QLSR SLQT LKDR LESL EHQL RANV SNAG LPGD FREV LQQR LGEL ERQL LRKV AELE DEKS LLHN ETSA HRQK TEST LNAL LQRV TELE RGNS AFKS PDAF KVSL PLRT NYLY GKI
Gene ID:4885
Uniprot:P47972
Cellular Location:Secreted
Calculated MW:47kDa
Observed MW:47kDa
Synonyms:NPTX2, NARP, NP-II, NP2
Background:This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
UniProt Protein Function:NPTX2: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q21.3-q22.1

NCBI Summary:This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]
UniProt Code:P47972
NCBI GenInfo Identifier:20981708
NCBI Gene ID:4885
NCBI Accession:P47972.2
UniProt Secondary Accession:P47972,Q86XV7, Q96G70, A4D267,
UniProt Related Accession:P47972
Molecular Weight:47,042 Da
NCBI Full Name:Neuronal pentraxin-2
NCBI Synonym Full Names:neuronal pentraxin 2
NCBI Official Symbol:NPTX2  
NCBI Official Synonym Symbols:NP2; NARP; NP-II  
NCBI Protein Information:neuronal pentraxin-2
UniProt Protein Name:Neuronal pentraxin-2
UniProt Synonym Protein Names:Neuronal pentraxin II; NP-II
Protein Family:Neuronal pentraxin
UniProt Gene Name:NPTX2  
UniProt Entry Name:NPTX2_HUMAN
Anti-NPTX2 Antibody (CAB12031)Western blot analysis of extracts of various cell lines, using NPTX2 antibody (CAB12031) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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