Name: Anti-NPSR1 Antibody (CAB16619)
Brand: Neuroscience
SKU: CAB16619
Availability: OutOfStock

Antibody Name:	Anti-NPSR1 Antibody
Antibody SKU:	CAB16619
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse lung, Mouse thymus

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	SKAK IKAI KYSI IIIL AFIC CWSP YFLF DILD NFNL LPDT QERF YASV IIQN LPAL NSAI NPLI YCVF SSSI SFPC REQR SQDS RMTF RERT ERHE MQIL SKPE FI
Gene ID:	387129
Uniprot:	Q6W5P4
Cellular Location:	Cell membrane, Cytoplasm, Multi-pass membrane protein
Calculated MW:	10-18kDa, 35-44kDa
Observed MW:	43kDa

Synonyms:

NPSR1, ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1

Background:

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	NPSR1: May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 9 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:neuropeptide receptor activity Biological Process: positive regulation of release of sequestered calcium ion into cytosol Disease: Asthma-related Traits, Susceptibility To, 2
NCBI Summary:	This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:	Q6W5P4
NCBI GenInfo Identifier:	74758626
NCBI Gene ID:	387129
NCBI Accession:	Q6W5P4.1
UniProt Secondary Accession:	Q6W5P4,Q2XP58, Q56H76, Q56H77, Q56H78, Q6JSL4, Q6JSL5 Q6JSL6, Q6JSL7, Q6JSL8, Q6W5P3, A2RTZ4,
UniProt Related Accession:	Q6W5P4
Molecular Weight:	10,612 Da
NCBI Full Name:	Neuropeptide S receptor
NCBI Synonym Full Names:	neuropeptide S receptor 1
NCBI Official Symbol:	NPSR1
NCBI Official Synonym Symbols:	GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
NCBI Protein Information:	neuropeptide S receptor
UniProt Protein Name:	Neuropeptide S receptor
UniProt Synonym Protein Names:	G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility
Protein Family:	Neuropeptide S receptor
UniProt Gene Name:	NPSR1
UniProt Entry Name:	NPSR1_HUMAN

Western blot analysis of extracts of various cell lines, using NPSR1 antibody (CAB16619) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.

Antibodies

Anti-NPSR1 Antibody (CAB16618)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)