Cell Biology Antibodies 7

Anti-NPRL2 Antibody (CAB16486)

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SKU:
CAB16486
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPRL2 Antibody
Antibody SKU:CAB16486
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NPRL2 (NP_006536.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:DU145, U-937, 293T, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NPRL2 (NP_006536.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSG CRIE CIFF SEFH PTLG PKIT YQVP EDFI SREL FDTV QVYI ITKP ELQN KLIT VTAM EKKL IGCP VCIE HKKY SRNA LLFN LGFV CDAQ AKTC ALEP IVKK LAGY LTTL ELES SFVS MEES KQKL VPIM TILL EELN ASGR CTLP IDES NTIH LKVI EQRP DPPV AQEY DVPV FTKD KEDF FNSQ WDLT TQQI LPYI DGFR HIQK ISAE ADVE LNLV
Gene ID:10641
Uniprot:Q8WTW4
Cellular Location:
Calculated MW:23kDa/43kDa
Observed MW:44kDa
Synonyms:NPRL2, FFEVF2, NPR2, NPR2L, TUSC4, NPR2-like
Background:
UniProt Protein Function:NPRL2: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. Belongs to the NPR2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Tumor suppressor; Inhibitor

Chromosomal Location of Human Ortholog: 3p21.3

Molecular Function:protein binding; GTPase activator activity; protein kinase activity

Biological Process: negative regulation of kinase activity; protein amino acid phosphorylation; positive regulation of GTPase activity

UniProt Code:Q8WTW4
NCBI GenInfo Identifier:47117604
NCBI Gene ID:10641
NCBI Accession:Q8WTW4.2
UniProt Secondary Accession:Q8WTW4,Q6FGS2, Q9Y249, Q9Y497, A8K831,
UniProt Related Accession:Q8WTW4
Molecular Weight:Observed MW 40kDaCalculated MW 23kDa/43kDa
NCBI Full Name:Nitrogen permease regulator 2-like protein
NCBI Synonym Full Names:nitrogen permease regulator-like 2 (S. cerevisiae)
NCBI Official Symbol:NPRL2  
NCBI Official Synonym Symbols:NPR2; NPR2L; TUSC4  
NCBI Protein Information:nitrogen permease regulator 2-like protein; G21 protein; 2810446G01Rik; gene 21 protein; NPR2-like protein; tumor suppressor candidate 4; homologous to yeast nitrogen permease (candidate tumor suppressor)
UniProt Protein Name:Nitrogen permease regulator 2-like protein
UniProt Synonym Protein Names:Gene 21 protein; G21 protein; Tumor suppressor candidate 4
Protein Family:Nitrogen permease regulator 2-like protein
UniProt Gene Name:NPRL2  
UniProt Entry Name:NPRL2_HUMAN
Anti-NPRL2 Antibody (CAB16486)Western blot analysis of extracts of various cell lines, using NPRL2 antibody (CAB16486) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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