Cell Biology Antibodies 11
Anti-NPR3 Antibody (CAB8138)
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- SKU:
- CAB8138
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | NPR3 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8138 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LVAH RHGM TSGD YAFF NIEL FNSS SYGD GSWK RGDK HDFE AKQA YSSL QTVT LLRT VKPE FEKF SMEV KSSV EKQG LNME DYVN MFVE GFHD AILL YVLA LHEV LRAG YSKK DGGK IIQQ TWNR TFEG IAGQ VSID ANGD RYGD FSVI AMTD VEAG TQEV IGDY FGKE GRFE MRPN VKYP WGPL KLRI DENR IVEH TNSS PCKS SGGL EESA VTGI VVGA LLGA GLLM AFYF FRKK YRIT IERR TQQE ESNL GKHR ELRE DSIR SHFS VA |
| Gene ID: | 4883 |
| Uniprot: | P17342 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 36kDa/59kDa |
| Observed MW: | 60kDa |
| Synonyms: | NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC |
| Background: | This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. |
| NCBI Summary: | This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P17342 |
| NCBI GenInfo Identifier: | 27735161 |
| NCBI Gene ID: | 4883 |
| NCBI Accession: | P17342.2 |
| UniProt Secondary Accession: | P17342,A2RRD1, B4DT84, E7EPG9, |
| UniProt Related Accession: | P17342 |
| Molecular Weight: | 36,656 Da |
| NCBI Full Name: | Atrial natriuretic peptide receptor 3 |
| NCBI Synonym Full Names: | natriuretic peptide receptor 3 |
| NCBI Official Symbol: | NPR3 |
| NCBI Official Synonym Symbols: | NPRC; ANP-C; ANPRC; NPR-C; ANPR-C; GUCY2B; C5orf23 |
| NCBI Protein Information: | atrial natriuretic peptide receptor 3 |
| UniProt Protein Name: | Atrial natriuretic peptide receptor 3 |
| UniProt Synonym Protein Names: | Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C |
| Protein Family: | Nitrogen permease regulator |
| UniProt Gene Name: | NPR3 |
| UniProt Entry Name: | ANPRC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NPR3 antibody (CAB8138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunofluorescence analysis of U2OS cells using NPR3 antibody (CAB8138) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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