Metabolism Antibodies 3

Anti-NPR2 Antibody (CAB16061)

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SKU:
CAB16061
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-NPR2 Antibody
Antibody SKU:CAB16061
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-320 of human NPR2 (NP_003986.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-320 of human NPR2 (NP_003986.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SAKN DHYR TLVR TGPS APKL GEFV VTLH GHFN WTAR AALL YLDA RTDD RPHY FTIE GVFE ALQG SNLS VQHQ VYAR EPGG PEQA THFI RANG RIVY ICGP LEML HEIL LQAQ RENL TNGD YVFF YLDV FGES LRAG PTRA TGRP WQDN RTRE QAQA LREA FQTV LVIT YREP PNPE YQEF QNRL LIRA RED
Gene ID:4882
Uniprot:P20594
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:111kDa/117kDa
Observed MW:117kDa
Synonyms:NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
Background:This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
UniProt Protein Function:ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, protein; Membrane protein, integral; Lyase; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; EC 4.6.1.2; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family

Chromosomal Location of Human Ortholog: 9p21-p12

Cellular Component: guanylate cyclase complex, soluble; integral to membrane; plasma membrane

Molecular Function:adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; natriuretic peptide receptor activity; peptide hormone binding; protein kinase activity; receptor activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of meiotic cell cycle; ossification; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; signal transduction

Disease: Acromesomelic Dysplasia, Maroteaux Type; Epiphyseal Chondrodysplasia, Miura Type; Short Stature With Nonspecific Skeletal Abnormalities

NCBI Summary:This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
UniProt Code:P20594
NCBI GenInfo Identifier:113916
NCBI Gene ID:4882
NCBI Accession:P20594.1
UniProt Secondary Accession:P20594,O60871, Q4VAK7, Q5TCV2, Q8TA93, Q9UQ50, B0ZBF2 B0ZBF3, D3DRP3, D3DRP4,
UniProt Related Accession:P20594
Molecular Weight:111,208 Da
NCBI Full Name:Atrial natriuretic peptide receptor 2
NCBI Synonym Full Names:natriuretic peptide receptor 2
NCBI Official Symbol:NPR2  
NCBI Official Synonym Symbols:AMDM; ANPb; ECDM; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B  
NCBI Protein Information:atrial natriuretic peptide receptor 2
UniProt Protein Name:Atrial natriuretic peptide receptor 2
UniProt Synonym Protein Names:Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B
UniProt Gene Name:NPR2  
UniProt Entry Name:ANPRB_HUMAN
Anti-NPR2 Antibody (CAB16061)Western blot analysis of extracts of 293T cells, using NPR2 antibody (CAB16061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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