Anti-NPPC Antibody (CAB20425)
- SKU:
- CAB20425
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CNP
- Synonyms:
- CNP2
Description
| Product Name: | NPPC Rabbit pAb |
| Product Code: | CAB20425 |
| Size: | 50uL, 100uL |
| Synonyms: | CNP, CNP2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NPPC (NP_077720.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NPPC (NP_077720.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4880 |
| Uniprot: | P23582 |
| Calculated MW: | 13kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Hormone; Secreted Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: extracellular region Molecular Function:receptor binding Biological Process: cGMP biosynthetic process; negative regulation of meiotic cell cycle; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P23582 |
| NCBI GenInfo Identifier: | 113850 |
| NCBI Gene ID: | 4880 |
| NCBI Accession: | P23582.1 |
| UniProt Secondary Accession: | P23582,Q4ZG41, |
| UniProt Related Accession: | P23582 |
| Molecular Weight: | 13,246 Da |
| NCBI Full Name: | C-type natriuretic peptide |
| NCBI Synonym Full Names: | natriuretic peptide C |
| NCBI Official Symbol: | NPPC |
| NCBI Official Synonym Symbols: | CNP; CNP2 |
| NCBI Protein Information: | C-type natriuretic peptide |
| UniProt Protein Name: | C-type natriuretic peptide |
| Protein Family: | C-type natriuretic peptide |
| UniProt Gene Name: | NPPC |
| UniProt Entry Name: | ANFC_HUMAN |
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