Cell Biology Antibodies 2

Anti-NPFFR2 Antibody (CAB10664)

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SKU:
CAB10664
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPFFR2 Antibody
Antibody SKU:CAB10664
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human NPFFR2 (NP_004876.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human NPFFR2 (NP_004876.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNSF FGTP AASW CLLE SDVS SAPD KEAG RERR ALSV QQRG GPAW SGSL EWSR QSAG DRRR LGLS RQTA KSSW SRSR DRTC CCRR AWWI LVPA ADRA RRER FIMN EKWD TNSS ENWH PIWN VNDT KHHL YSDI NITY VNYY
Gene ID:10886
Uniprot:Q9Y5X5
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:15kDa/48kDa/49kDa/60kDa
Observed MW:48kDa
Synonyms:NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR
Background:This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: actin cytoskeleton; integral to plasma membrane; plasma membrane

Molecular Function:G-protein coupled receptor activity; neuropeptide receptor activity; peptide binding

Biological Process: cellular response to hormone stimulus; detection of abiotic stimulus; G-protein coupled receptor protein signaling pathway; synaptic transmission

NCBI Summary:This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
UniProt Code:Q9Y5X5
NCBI GenInfo Identifier:13878604
NCBI Gene ID:10886
NCBI Accession:Q9Y5X5.2
UniProt Secondary Accession:Q9Y5X5,Q96RV1, Q9NR49,
UniProt Related Accession:Q9Y5X5
Molecular Weight:15,055 Da
NCBI Full Name:Neuropeptide FF receptor 2
NCBI Synonym Full Names:neuropeptide FF receptor 2
NCBI Official Symbol:NPFFR2  
NCBI Official Synonym Symbols:GPR74; NPFF2; NPGPR; HLWAR77  
NCBI Protein Information:neuropeptide FF receptor 2
UniProt Protein Name:Neuropeptide FF receptor 2
UniProt Synonym Protein Names:G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; Neuropeptide G-protein coupled receptor
Protein Family:Neuropeptide FF receptor
UniProt Gene Name:NPFFR2  
UniProt Entry Name:NPFF2_HUMAN
Anti-NPFFR2 Antibody (CAB10664)Western blot analysis of extracts of various cell lines, using NPFFR2 antibody (CAB10664) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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