Cell Biology Antibodies 10

Anti-NPFF Antibody (CAB7020)

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SKU:
CAB7020
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NPFF Antibody
Antibody SKU:CAB7020
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:Rat plasma
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AEED SEPL PPQD AQTS GSLL HYLL QAME RPGR SQAF LFQP QRFG RNTQ GSWR NEWL SPRA GEGL NSQF WSLA APQR FGKK
Gene ID:8620
Uniprot:O15130
Cellular Location:Secreted
Calculated MW:12kDa
Observed MW:12kDa
Synonyms:NPFF, FMRFAL
Background:This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
UniProt Protein Function:NPFF: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Belongs to the FARP (FMRFamide related peptide) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: extracellular space; dendrite; extracellular region; perikaryon; nerve terminal; vesicle

Molecular Function:neuropeptide hormone activity; G-protein-coupled receptor binding; receptor binding

Biological Process: response to drug; negative regulation of heart rate; maternal process involved in pregnancy; response to morphine; negative regulation of appetite; negative regulation of insulin secretion; vasopressin secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; spinal cord development; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; positive regulation of blood pressure; acute inflammatory response to antigenic stimulus

NCBI Summary:This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Code:O15130
NCBI GenInfo Identifier:8134595
NCBI Gene ID:8620
NCBI Accession:O15130.1
UniProt Related Accession:O15130
Molecular Weight:12kDa
NCBI Full Name:Pro-FMRFamide-related neuropeptide FF
NCBI Synonym Full Names:neuropeptide FF-amide peptide precursor
NCBI Official Symbol:NPFF  
NCBI Official Synonym Symbols:FMRFAL  
NCBI Protein Information:pro-FMRFamide-related neuropeptide FF
UniProt Protein Name:Pro-FMRFamide-related neuropeptide FF
UniProt Synonym Protein Names:FMRFamide-related peptidesCleaved into the following 3 chains:Neuropeptide SF; NPSF; Neuropeptide FF; NPFF; Neuropeptide AF; NPAF
Protein Family:Pro-FMRFamide-related neuropeptide
UniProt Gene Name:NPFF  
UniProt Entry Name:NPFF_HUMAN
Anti-NPFF Antibody (CAB7020)Western blot analysis of extracts of Rat plasma, using NPFF antibody (CAB7020) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min.
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