Cell Biology Antibodies 7
Anti-NPB Antibody (CAB16612)
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- SKU:
- CAB16612
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NPB Antibody |
| Antibody SKU: | CAB16612 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human NPB (NP_683694.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW480, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human NPB (NP_683694.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARS ATLA AAAL ALCL LLAP PGLA WYKP AAGH SSYS VGRA AGLL SGLR RSPY ARRS QPYR GAEP PGGA GASP ELQL HPRL RSLA VCVQ DVAP NLQR CERL PDGR GTYQ CKAN VFLS LRAA DCLA A |
| Gene ID: | 256933 |
| Uniprot: | Q8NG41 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa |
| Observed MW: | 13kDa |
| Synonyms: | NPB, L7, PPL7, PPNPB |
| Background: | This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. |
| UniProt Protein Function: | NPB: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: extracellular region Molecular Function:protein binding; G-protein-coupled receptor binding Biological Process: G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway |
| NCBI Summary: | This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q8NG41 |
| NCBI GenInfo Identifier: | 22507403 |
| NCBI Gene ID: | 256933 |
| NCBI Accession: | NP_683694.1 |
| UniProt Related Accession: | Q8NG41 |
| Molecular Weight: | 13kDa |
| NCBI Full Name: | neuropeptide B preproprotein |
| NCBI Synonym Full Names: | neuropeptide B |
| NCBI Official Symbol: | NPB |
| NCBI Official Synonym Symbols: | L7; PPL7; PPNPB |
| NCBI Protein Information: | neuropeptide B |
| UniProt Protein Name: | Neuropeptide B |
| UniProt Synonym Protein Names: | Preproprotein L7 |
| Protein Family: | Neuropeptide |
| UniProt Gene Name: | NPB |
| UniProt Entry Name: | NPB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NPB antibody (CAB16612) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using NPB Rabbit pAb (CAB16612) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using NPB Rabbit pAb (CAB16612) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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