Cell Biology Antibodies 17
Anti-NOXA2/p67phox Antibody (CAB3703)
- SKU:
- CAB3703
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NOXA2/p67phox Antibody |
| Antibody SKU: | CAB3703 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NOXA2/p67phox |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat lung |
| Immunogen: | A synthesized peptide derived from human NOXA2/p67phox |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4688 |
| Uniprot: | P19878 |
| Cellular Location: | |
| Calculated MW: | 67kDa |
| Observed MW: | 67KDa |
| Synonyms: | NCF-2, NOXA2, P67-PHOX, P67PHOX |
| Background: | This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] |
| UniProt Protein Function: | p67phox: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 1q25 Cellular Component: cytoplasm; acrosome; nucleolus; cytosol; NADPH oxidase complex Molecular Function:protein C-terminus binding; protein binding; electron carrier activity; Rac GTPase binding Biological Process: respiratory burst; response to drug; interaction with host; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; response to lipopolysaccharide; cellular response to hormone stimulus; antigen processing and presentation of peptide antigen via MHC class I; response to hyperoxia; positive regulation of neuron apoptosis; response to glucose stimulus; cellular defense response; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; response to activity; vascular endothelial growth factor receptor signaling pathway; response to progesterone stimulus; superoxide release; positive regulation of blood pressure; aging Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Ii |
| NCBI Summary: | This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P19878 |
| NCBI GenInfo Identifier: | 1346669 |
| NCBI Gene ID: | 4688 |
| NCBI Accession: | P19878.2 |
| UniProt Secondary Accession: | P19878,Q2PP06, Q8NFC7, Q9BV51, B2R6Q1, B4DKQ7, B4DQA7 E9PHJ2, E9PHX3, |
| UniProt Related Accession: | P19878 |
| Molecular Weight: | 50,337 Da |
| NCBI Full Name: | Neutrophil cytosol factor 2 |
| NCBI Synonym Full Names: | neutrophil cytosolic factor 2 |
| NCBI Official Symbol: | NCF2 |
| NCBI Official Synonym Symbols: | NCF-2; NOXA2; P67PHOX; P67-PHOX |
| NCBI Protein Information: | neutrophil cytosol factor 2; NADPH oxidase activator 2; 67 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 2; chronic granulomatous disease, autosomal 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) |
| UniProt Protein Name: | Neutrophil cytosol factor 2 |
| UniProt Synonym Protein Names: | 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phox |
| UniProt Gene Name: | NCF2 |
| UniProt Entry Name: | NCF2_HUMAN |
 | Western blot - NOXA2/p67phox Rabbit mAb (CAB3703) |
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