Cell Biology Antibodies 8

Anti-NOX3 Antibody (CAB3677)

(No reviews yet) Write a Review
SKU:
CAB3677
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NOX3 Antibody
Antibody SKU:CAB3677
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 223-395 of human NOX3 (NP_056533.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, Mouse brain, Mouse pancreas, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 223-395 of human NOX3 (NP_056533.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GRIV RGQT QDSL SLHN ITFC RDRY AEWQ TVAQ CPVP QFSG KEPS AWKW ILGP VVLY ACER IIRF WRFQ QEVV ITKV VSHP SGVL ELHM KKRG FKMA PGQY ILVQ CPAI SSLE WHPF TLTS APQE DFFS VHIR AAGD WTAA LLEA FGAE GQAL QEPW SLPR LAVD GPFG TALT D
Gene ID:50508
Uniprot:Q9HBY0
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:64kDa
Observed MW:65kDa
Synonyms:NOX3, GP91-3, MOX-2
Background:This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
UniProt Protein Function:NOX3: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
UniProt Protein Details:

Protein type:Membrane protein, integral; Oxidoreductase; EC 1.6.3.-; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: plasma membrane

NCBI Summary:This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
UniProt Code:Q9HBY0
NCBI GenInfo Identifier:74752785
NCBI Gene ID:50508
NCBI Accession:Q9HBY0.1
UniProt Secondary Accession:Q9HBY0,Q9HBJ9,
UniProt Related Accession:Q9HBY0
Molecular Weight:64,935 Da
NCBI Full Name:NADPH oxidase 3
NCBI Synonym Full Names:NADPH oxidase 3
NCBI Official Symbol:NOX3  
NCBI Official Synonym Symbols:MOX-2; GP91-3  
NCBI Protein Information:NADPH oxidase 3
UniProt Protein Name:NADPH oxidase 3
UniProt Synonym Protein Names:Mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3
Protein Family:NADPH oxidase
UniProt Gene Name:NOX3  
UniProt Entry Name:NOX3_HUMAN
Anti-NOX3 Antibody (CAB3677)Western blot analysis of extracts of various cell lines, using NOX3 antibody (CAB3677) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
View AllClose

0 Reviews

View AllClose

Related Products