Cell Biology Antibodies 2

Anti-NOVA1 Antibody (CAB12030)

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SKU:
CAB12030
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NOVA1 Antibody
Antibody SKU:CAB12030
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 408-507 of human NOVA1 (NP_002506.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-251MG, SH-SY5Y
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 408-507 of human NOVA1 (NP_002506.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SAIL GTEK STDG SKDV VEIA VPEN LVGA ILGK GGKT LVEY QELT GARI QISK KGEF VPGT RNRK VTIT GTPA ATQA AQYL ITQR ITYE QGVR AANP QKVG
Gene ID:4857
Uniprot:P51513
Cellular Location:Nucleus
Calculated MW:19kDa/49kDa/51kDa/52kDa
Observed MW:60kDa
Synonyms:NOVA1, Nova-1
Background:This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
UniProt Protein Function:NOVA1: May regulate RNA splicing or metabolism in a specific subset of developing neurons. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 14q

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function:RNA binding

Biological Process: locomotory behavior; RNA processing; RNA splicing; synaptic transmission

NCBI Summary:This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P51513
NCBI GenInfo Identifier:1709303
NCBI Gene ID:4857
NCBI Accession:P51513.1
UniProt Secondary Accession:P51513,Q6B004, A8K0S4, A8K4Q7, D3DS81, D3DS82,
UniProt Related Accession:P51513
Molecular Weight:49,253 Da
NCBI Full Name:RNA-binding protein Nova-1
NCBI Synonym Full Names:NOVA alternative splicing regulator 1
NCBI Official Symbol:NOVA1  
NCBI Official Synonym Symbols:Nova-1  
NCBI Protein Information:RNA-binding protein Nova-1
UniProt Protein Name:RNA-binding protein Nova-1
UniProt Synonym Protein Names:Neuro-oncological ventral antigen 1; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1
Protein Family:RNA-binding protein
UniProt Gene Name:NOVA1  
UniProt Entry Name:NOVA1_HUMAN
Anti-NOVA1 Antibody (CAB12030)Western blot analysis of extracts of various cell lines, using NOVA1 antibody (CAB12030) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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