Cell Biology Antibodies 6
Anti-NOSTRIN Antibody (CAB15938)
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- SKU:
- CAB15938
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NOSTRIN Antibody |
| Antibody SKU: | CAB15938 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-506 of human NOSTRIN (NP_001034813.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-506 of human NOSTRIN (NP_001034813.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NCYQ SILE LEKE RIQL LCNN LNQY SQHI SLFG QTLT TCHT QIHC AISK IDIE KDIQ AVME ETAI LSTE NKSE FLLT DYFE EDPN SAMD KERR KSLL KPKL LRLQ RDIE KASK DKEG LERM LKTY SSTS SFSD AKSQ KDTA ALMD ENNL KLDL LEAN SYKL SSML AELE QRPQ PSHP CSNS IFRW REKE HTHS YVKI SRPF LMKR LENI VSKA SSGG QSNP GSST PAPG AAQL SSRL CKAL YSFQ ARQD DELN LEKG DIVI IHEK KEGG WWFG SLNG KKGH FPAA YVEE LPSN AGNT ATKA |
| Gene ID: | 115677 |
| Uniprot: | Q8IVI9 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Nucleus, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 48kDa/54kDa/57kDa/64kDa |
| Observed MW: | 57kDa |
| Synonyms: | NOSTRIN, DaIP2, nostrin |
| Background: | Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production. |
| UniProt Protein Function: | NOSTRIN: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: regulation of nitric-oxide synthase activity |
| NCBI Summary: | Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q8IVI9 |
| NCBI GenInfo Identifier: | 317373401 |
| NCBI Gene ID: | 115677 |
| NCBI Accession: | Q8IVI9.2 |
| UniProt Secondary Accession: | Q8IVI9,Q27HG3, Q53S62, Q96CJ9, A8K2I9, B3KSF5, E7EPT9 |
| UniProt Related Accession: | Q8IVI9 |
| Molecular Weight: | 64,364 Da |
| NCBI Full Name: | Nostrin |
| NCBI Synonym Full Names: | nitric oxide synthase trafficking |
| NCBI Official Symbol: | NOSTRIN |
| NCBI Official Synonym Symbols: | DaIP2 |
| NCBI Protein Information: | nostrin |
| UniProt Protein Name: | Nostrin |
| UniProt Synonym Protein Names: | BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer |
| Protein Family: | Nostrin |
| UniProt Gene Name: | NOSTRIN |
| UniProt Entry Name: | NOSTN_HUMAN |
 | Western blot analysis of extracts of mouse brain, using NOSTRIN antibody (CAB15938) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of U-2 OS cells using NOSTRIN Rabbit pAb (CAB15938) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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