Cell Biology Antibodies 4

Anti-NOP58 Antibody (CAB14129)

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SKU:
CAB14129
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NOP58 Antibody
Antibody SKU:CAB14129
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-529 of human NOP58 (NP_057018.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A375, HeLa, SH-SY5Y, K-562, Jurkat, HepG2, Mouse liver, Mouse brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-529 of human NOP58 (NP_057018.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RMLA AKTV LAIR YDAF GEDS SSAM GVEN RAKL EARL RTLE DRGI RKIS GTGK ALAK TEKY EHKS EVKT YDPS GDST LPTC SKKR KIEQ VDKE DEIT EKKA KKAK IKVK VEEE EEEK VAEE EETS VKKK KKRG KKKH IKEE PLSE EEPC TSTA IASP EKKK KKKK KREN ED
Gene ID:51602
Uniprot:Q9Y2X3
Cellular Location:Nucleus, nucleolus, nucleoplasm
Calculated MW:59kDa
Observed MW:68kDa
Synonyms:NOP58, HSPC120, NOP5, NOP5/NOP58
Background:The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs.
UniProt Protein Function:NOP5: Required for 60S ribosomal subunit biogenesis. Belongs to the NOP5/NOP56 family.
UniProt Protein Details:

Protein type:Nucleolus; Cell development/differentiation; RNA-binding

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: Cajal body; small nucleolar ribonucleoprotein complex; membrane; cytoplasm; nucleolus; nucleus

Molecular Function:snoRNA binding; protein binding

Biological Process: rRNA modification; snRNP protein import into nucleus; cell growth; rRNA processing

UniProt Code:Q9Y2X3
NCBI GenInfo Identifier:17380155
NCBI Gene ID:51602
NCBI Accession:Q9Y2X3.1
UniProt Secondary Accession:Q9Y2X3,Q53SA4, Q6PK08, Q9P036, Q9UFN3,
UniProt Related Accession:Q9Y2X3
Molecular Weight:529
NCBI Full Name:Nucleolar protein 58
NCBI Synonym Full Names:NOP58 ribonucleoprotein
NCBI Official Symbol:NOP58  
NCBI Official Synonym Symbols:NOP5; HSPC120; NOP5/NOP58  
NCBI Protein Information:nucleolar protein 58; nucleolar protein NOP5/NOP58; NOP58 ribonucleoprotein homolog
UniProt Protein Name:Nucleolar protein 58
UniProt Synonym Protein Names:Nucleolar protein 5
Protein Family:Nucleolar protein
UniProt Gene Name:NOP58  
UniProt Entry Name:NOP58_HUMAN
Anti-NOP58 Antibody (CAB14129)Western blot analysis of extracts of various cell lines, using NOP58 antibody (CAB14129) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-NOP58 Antibody (CAB14129)Confocal immunofluorescence analysis of U2OS cells using NOP58 Polyclonal Antibody (CAB14129) at dilution of 1:100. Blue: DAPI for nuclear staining.
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Cell Biology Antibodies 9

OverviewProduct Name:NOP58 Rabbit pAbProduct Code:CAB4749Size:20uL, 50uL, 100uLSynonyms:NOP58, HSPC120, NOP5, NOP5/NOP58