Cell Biology Antibodies 7

Anti-NOMO2 Antibody (CAB16614)

(No reviews yet) Write a Review
SKU:
CAB16614
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NOMO2 Antibody
Antibody SKU:CAB16614
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 873-1222 of human NOMO2 (NP_001004060.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:BxPC3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 873-1222 of human NOMO2 (NP_001004060.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YALA GVSF EIKA EDDQ PLPG VLLS LSGG LFRS NLLT QDNG ILTF SNLS PGQY YFKP MMKE FRFE PSSQ MIEV QEGQ NLKI TITG YRTA YSCY GTVS SLNG EPEQ GVAM EAVG QNDC SIYG EDTV TDEE GKFR LRGL LPGC VYHV QLKA EGND HIER ALPH HRVI EVGN NDID DVNI IVFR QINQ FDLS GNVI TSSE YLPT LWVK LYKS ENLD NPIQ TVSL GQSL FFHF PPLL RDGE NYVV LLDS TLPR SQYD YILP QVSF TAVG YHKH ITLI FNPT RKLP EQDI AQGS YIAL PLTL LVLL AGYN HDKL IPLL LQLT SRLQ GVGA LGQA ASDN SGPE DAKR QAKK QKTR RT
Gene ID:283820
Uniprot:Q5JPE7
Cellular Location:Endoplasmic reticulum membrane, Single-pass membrane protein
Calculated MW:122kDa/134kDa/139kDa
Observed MW:139kDa
Synonyms:NOMO2, Nomo, PM5
Background:This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described.
UniProt Protein Function:NOMO2: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function:protein binding; carbohydrate binding

NCBI Summary:This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q5JPE7
NCBI GenInfo Identifier:51944971
NCBI Gene ID:283820
NCBI Accession:NP_001004060.1
UniProt Secondary Accession:Q5JPE7,Q4G177,
UniProt Related Accession:Q5JPE7
Molecular Weight:139,439 Da
NCBI Full Name:nodal modulator 2 isoform 1
NCBI Synonym Full Names:NODAL modulator 2
NCBI Official Symbol:NOMO2  
NCBI Official Synonym Symbols:PM5; Nomo  
NCBI Protein Information:nodal modulator 2; pM5 protein 2; pM5 protein, centromeric copy
UniProt Protein Name:Nodal modulator 2
UniProt Synonym Protein Names:pM5 protein 2
Protein Family:Nodal modulator
UniProt Gene Name:NOMO2  
UniProt Entry Name:NOMO2_HUMAN
Anti-NOMO2 Antibody (CAB16614)Western blot analysis of extracts of BxPC3 cells, using NOMO2 antibody (CAB16614) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
View AllClose

0 Reviews

View AllClose

Related Products