Cell Biology Antibodies 6

Anti-NOCT Antibody (CAB15805)

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SKU:
CAB15805
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NOCT Antibody
Antibody SKU:CAB15805
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 132-431 of human NOCT (NP_036250.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 132-431 of human NOCT (NP_036250.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRTD CPST HPPI RVMQ WNIL AQAL GEGK DNFV QCPV EALK WEER KCLI LEEI LAYQ PDIL CLQE VDHY FDTF QPLL SRLG YQGT FFPK PWSP CLDV EHNN GPDG CALF FLQN RFKL VNSA NIRL TAMT LKTN QVAI AQTL ECKE SGRQ FCIA VTHL KART GWER FRSA QGCD LLQN LQNI TQGA KIPL IVCG DFNA EPTE EVYK HFAS SSLN LNSA YKLL SADG QSEP PYTT WKIR TSGE CRHT LDYI WYSK HALN VRSA LDLL TEEQ IGPN RLPS FNYP SDHL SLVC DFSF TEES DGLS
Gene ID:25819
Uniprot:Q9UK39
Cellular Location:Cytoplasm, Nucleus, perinuclear region
Calculated MW:48kDa
Observed MW:48kDa
Synonyms:NOCT, CCR4L, CCRN4L, Ccr4c, NOC, nocturnin
Background:The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
UniProt Protein Function:CCRN4L: Component of the circadian clock or downstream effector of clock function. Exhibits a high amplitude circadian rhythm with maximal levels in early evening. In constant darkness or constant light, the amplitude of the rhythm decreases. Belongs to the CCR4/nocturin family.
UniProt Protein Details:

Protein type:EC 3.1.13.4

Chromosomal Location of Human Ortholog: 4q31.1

Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function:mRNA binding; poly(A)-specific ribonuclease activity; transcription factor activity

Biological Process: circadian regulation of gene expression; circadian rhythm; mRNA stabilization; negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; regulation of circadian rhythm; response to extracellular stimulus; response to lipopolysaccharide; transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UK39
NCBI GenInfo Identifier:212276446
NCBI Gene ID:25819
NCBI Accession:Q9UK39.2
UniProt Secondary Accession:Q9UK39,Q14D51, Q9HD93, Q9HD94, Q9HD95, D3DNY5,
UniProt Related Accession:Q9UK39
Molecular Weight:48,196 Da
NCBI Full Name:Nocturnin
NCBI Synonym Full Names:nocturnin
NCBI Official Symbol:NOCT  
NCBI Official Synonym Symbols:NOC; CCR4L; Ccr4c; CCRN4L  
NCBI Protein Information:nocturnin
UniProt Protein Name:Nocturnin
UniProt Synonym Protein Names:Carbon catabolite repression 4-like protein; Circadian deadenylase NOC
UniProt Gene Name:NOCT  
UniProt Entry Name:NOCT_HUMAN
Anti-NOCT Antibody (CAB15805)Western blot analysis of extracts of rat brain, using NOCT antibody (CAB15805) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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