Cell Biology Antibodies 15

Anti-NOC2L Antibody (CAB17918)

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SKU:
CAB17918
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NOC2L Antibody
Antibody SKU:CAB17918
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human NOC2L.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human NOC2L.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26155
Uniprot:Q9Y3T9
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:NIR, NET7, NET15, PPP1R112, NOC2L
Background:Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) .
UniProt Protein Function:NOC2L: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Belongs to the NOC2 family.
UniProt Protein Details:

Protein type:Transcription factor; RNA-binding; Histone-binding; Nucleolus

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function:protein binding; histone binding; nucleosome binding; chromatin binding; transcription corepressor activity

Biological Process: nucleolus to nucleoplasm transport; transcription, DNA-dependent; apoptosis; chromatin assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; negative regulation of histone acetylation

NCBI Summary:Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9Y3T9
NCBI GenInfo Identifier:317373580
NCBI Gene ID:26155
NCBI Accession:Q9Y3T9.4
UniProt Secondary Accession:Q9Y3T9,Q5SVA3, Q9BTN6,
UniProt Related Accession:Q9Y3T9
Molecular Weight:84,919 Da
NCBI Full Name:Nucleolar complex protein 2 homolog
NCBI Synonym Full Names:nucleolar complex associated 2 homolog (S. cerevisiae)
NCBI Official Symbol:NOC2L  
NCBI Official Synonym Symbols:NIR; NET7; NET15; PPP1R112  
NCBI Protein Information:nucleolar complex protein 2 homolog; NOC2-like protein; novel INHAT (inhibitor of histone acetyltransferase) repressor; novel INHAT repressor; protein NOC2 homolog; protein phosphatase 1, regulatory subunit 12
UniProt Protein Name:Nucleolar complex protein 2 homolog
UniProt Synonym Protein Names:NOC2-like protein; Novel INHAT repressor
UniProt Gene Name:NOC2L  
UniProt Entry Name:NOC2L_HUMAN
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