Cell Biology Antibodies 15
Anti-NOC2L Antibody (CAB17918)
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- SKU:
- CAB17918
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NOC2L Antibody |
| Antibody SKU: | CAB17918 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human NOC2L. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human NOC2L. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 26155 |
| Uniprot: | Q9Y3T9 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NIR, NET7, NET15, PPP1R112, NOC2L |
| Background: | Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) . |
| UniProt Protein Function: | NOC2L: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Belongs to the NOC2 family. |
| UniProt Protein Details: | Protein type:Transcription factor; RNA-binding; Histone-binding; Nucleolus Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: nucleoplasm; nucleolus; nucleus Molecular Function:protein binding; histone binding; nucleosome binding; chromatin binding; transcription corepressor activity Biological Process: nucleolus to nucleoplasm transport; transcription, DNA-dependent; apoptosis; chromatin assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; negative regulation of histone acetylation |
| NCBI Summary: | Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9Y3T9 |
| NCBI GenInfo Identifier: | 317373580 |
| NCBI Gene ID: | 26155 |
| NCBI Accession: | Q9Y3T9.4 |
| UniProt Secondary Accession: | Q9Y3T9,Q5SVA3, Q9BTN6, |
| UniProt Related Accession: | Q9Y3T9 |
| Molecular Weight: | 84,919 Da |
| NCBI Full Name: | Nucleolar complex protein 2 homolog |
| NCBI Synonym Full Names: | nucleolar complex associated 2 homolog (S. cerevisiae) |
| NCBI Official Symbol: | NOC2L |
| NCBI Official Synonym Symbols: | NIR; NET7; NET15; PPP1R112 |
| NCBI Protein Information: | nucleolar complex protein 2 homolog; NOC2-like protein; novel INHAT (inhibitor of histone acetyltransferase) repressor; novel INHAT repressor; protein NOC2 homolog; protein phosphatase 1, regulatory subunit 12 |
| UniProt Protein Name: | Nucleolar complex protein 2 homolog |
| UniProt Synonym Protein Names: | NOC2-like protein; Novel INHAT repressor |
| UniProt Gene Name: | NOC2L |
| UniProt Entry Name: | NOC2L_HUMAN |
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