Cell Biology Antibodies 13

Anti-NOB1 Antibody (CAB17690)

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SKU:
CAB17690
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NOB1 Antibody
Antibody SKU:CAB17690
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human NOB1 (NP_054781.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, LO2, rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human NOB1 (NP_054781.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPV EHVV ADAG AFLR HAAL QDIG KNIY TIRE VVTE IRDK ATRR RLAV LPYE LRFK EPLP EYVR LVTE FSKK TGDY PSLS ATDI QVLA LTYQ LEAE FVGV SHLK QEPQ KVKV SSSI QHPE TPLH ISGF HLPY KPKP PQET EKGH SACE PENL EFSS FMFW RNPL PNID HELQ ELLI DRGE DVPS EEEE EEEN GFED RKDD SDDD GGGW ITPS NIKQ IQQE LEQC DVPE DV
Gene ID:28987
Uniprot:Q9ULX3
Cellular Location:
Calculated MW:
Observed MW:47kDa
Anti-NOB1 Antibody (CAB17690)Western blot - NOB1 Polyclonal Antibody (CAB17690)
Synonyms:ART-4, MST158, MSTP158, NOB1P, PSMD8BP1, NOB1
Background:In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
UniProt Protein Function:NOB1P: May play a role in mRNA degradation. Belongs to the NOB1 family.
UniProt Protein Details:

Protein type:RNA processing

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: cytosol; nucleolar preribosome, small subunit precursor; nucleoplasm

Molecular Function:endoribonuclease activity

Biological Process: cleavages during rRNA processing; maturation of SSU-rRNA; rRNA processing

NCBI Summary:In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
UniProt Code:Q9ULX3
NCBI GenInfo Identifier:74753398
NCBI Gene ID:28987
NCBI Accession:Q9ULX3.1
UniProt Secondary Accession:Q9ULX3,Q7L6B7, Q7M4M4, Q7Z4B5, Q9NWB0,
UniProt Related Accession:Q9ULX3
Molecular Weight:46,675 Da
NCBI Full Name:RNA-binding protein NOB1
NCBI Synonym Full Names:NIN1/PSMD8 binding protein 1 homolog
NCBI Official Symbol:NOB1  
NCBI Official Synonym Symbols:ART-4; NOB1P; MST158; MSTP158; PSMD8BP1  
NCBI Protein Information:RNA-binding protein NOB1
UniProt Protein Name:RNA-binding protein NOB1
UniProt Synonym Protein Names:Phosphorylation regulatory protein HP-10; Protein ART-4
Protein Family:Endoribonuclease
UniProt Gene Name:NOB1  
UniProt Entry Name:NOB1_HUMAN
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