Metabolism Antibodies 2
Anti-NMNAT1 Antibody (CAB4937)
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- SKU:
- CAB4937
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NMNAT1
- Synonyms:
- LCA9
- Synonyms:
- NMNAT
- Synonyms:
- PNAT1
- Research Area:
- Metabolism
Description
| Product Name: | NMNAT1 Rabbit pAb |
| Product Code: | CAB4937 |
| Size: | 20uL, 100uL |
| Synonyms: | NMNAT1, LCA9, NMNAT, PNAT1 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human NMNAT1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | Human brain |
| Immunogen: | A synthetic Peptide of human NMNAT1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 64802 |
| Uniprot: | Q9HAN9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 31kDa |
| Observed MW: | 36kDa |
| UniProt Protein Function: | NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; EC 2.7.7.1 Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process Disease: Leber Congenital Amaurosis 9 |
| NCBI Summary: | This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9HAN9 |
| NCBI GenInfo Identifier: | 30580491 |
| NCBI Gene ID: | 64802 |
| NCBI Accession: | Q9HAN9.1 |
| UniProt Secondary Accession: | Q9HAN9,Q8TAE9, Q9H247, Q9H6B6, B1AN63, |
| UniProt Related Accession: | Q9HAN9 |
| Molecular Weight: | 279 |
| NCBI Full Name: | Nicotinamide mononucleotide adenylyltransferase 1 |
| NCBI Synonym Full Names: | nicotinamide nucleotide adenylyltransferase 1 |
| NCBI Official Symbol: | NMNAT1 |
| NCBI Official Synonym Symbols: | LCA9; NMNAT; PNAT1 |
| NCBI Protein Information: | nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1 |
| UniProt Protein Name: | Nicotinamide mononucleotide adenylyltransferase 1 |
| UniProt Synonym Protein Names: | Nicotinate-nucleotide adenylyltransferase 1 (EC:2.7.7.18); NaMN adenylyltransferase 1 |
| UniProt Gene Name: | NMNAT1 |
| UniProt Entry Name: | NMNA1_HUMAN |
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