Metabolism Antibodies 2

Anti-NMNAT1 Antibody (CAB4937)

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SKU:
CAB4937
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NMNAT1
Synonyms:
LCA9
Synonyms:
NMNAT
Synonyms:
PNAT1
Research Area:
Metabolism

Description

Product Name:NMNAT1 Rabbit pAb
Product Code:CAB4937
Size:20uL, 100uL
Synonyms:NMNAT1, LCA9, NMNAT, PNAT1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human NMNAT1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:Human brain
Immunogen:A synthetic Peptide of human NMNAT1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64802
Uniprot:Q9HAN9
Cellular Location:Nucleus
Calculated MW:31kDa
Observed MW:36kDa
UniProt Protein Function:NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family.
UniProt Protein Details:

Protein type:EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; EC 2.7.7.1

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process

Disease: Leber Congenital Amaurosis 9

NCBI Summary:This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
UniProt Code:Q9HAN9
NCBI GenInfo Identifier:30580491
NCBI Gene ID:64802
NCBI Accession:Q9HAN9.1
UniProt Secondary Accession:Q9HAN9,Q8TAE9, Q9H247, Q9H6B6, B1AN63,
UniProt Related Accession:Q9HAN9
Molecular Weight:279
NCBI Full Name:Nicotinamide mononucleotide adenylyltransferase 1
NCBI Synonym Full Names:nicotinamide nucleotide adenylyltransferase 1
NCBI Official Symbol:NMNAT1  
NCBI Official Synonym Symbols:LCA9; NMNAT; PNAT1  
NCBI Protein Information:nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1
UniProt Protein Name:Nicotinamide mononucleotide adenylyltransferase 1
UniProt Synonym Protein Names:Nicotinate-nucleotide adenylyltransferase 1 (EC:2.7.7.18); NaMN adenylyltransferase 1
UniProt Gene Name:NMNAT1  
UniProt Entry Name:NMNA1_HUMAN
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