Name: Anti-NME8 Antibody (CAB17153)
Brand: Cell Biology Antibodies 13
SKU: CAB17153
Availability: OutOfStock

Antibody Name:	Anti-NME8 Antibody
Antibody SKU:	CAB17153
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 299-588 of human NME8 (NP_057700.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	U-87MG, SH-SY5Y, Jurkat

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 299-588 of human NME8 (NP_057700.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	FMDA FFPD FKKM KSMK LEKT LALL RPNL FHER KDDV LRII KDED FKIL EQRQ VVLS EKEA QALC KEYE NEDY FNKL IENM TSGP SLAL VLLR DNGL QYWK QLLG PRTV EEAI EYFP ESLC AQFA MDSL PVNQ LYGS DSLE TAER EIQH FFPL QSTL GLIK PHAT SEQR EQIL KIVK EAGF DLTQ VKKM FLTP EQIE KIYP KVTG KDFY KDLL EMLS VGPS MVMI LTKW NAVA EWRR LMGP TDPE EAKL LSPD SIRA QFGI SKLK NIVH GASN AYEA KEVV NRLF EDPE EN
Gene ID:	51314
Uniprot:	Q8N427
Cellular Location:
Calculated MW:	67kDa
Observed MW:	67kDa

Western blot - NME8 Rabbit pAb (CAB17153)

Synonyms:

NME8, CILD6, HEL-S-99, NM23-H8, SPTRX2, TXNDC3, sptrx-2

Background:

This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.

UniProt Protein Function:	TXNDC3: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
UniProt Protein Details:	Protein type:Oxidoreductase; Kinase, nucleoside diphosphate; Other group; NDK family Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: cytoplasm; intracellular Molecular Function:nucleoside diphosphate kinase activity; ATP binding Biological Process: GTP biosynthetic process; CTP biosynthetic process; cell redox homeostasis; multicellular organismal development; UTP biosynthetic process; nucleoside diphosphate phosphorylation; spermatogenesis; cell differentiation Disease: Ciliary Dyskinesia, Primary, 6
NCBI Summary:	This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
UniProt Code:	Q8N427
NCBI GenInfo Identifier:	148839372
NCBI Gene ID:	51314
NCBI Accession:	NP_057700.3
UniProt Secondary Accession:	Q8N427,Q9NZH1,
UniProt Related Accession:	Q8N427
Molecular Weight:	67,270 Da
NCBI Full Name:	thioredoxin domain-containing protein 3
NCBI Synonym Full Names:	NME/NM23 family member 8
NCBI Official Symbol:	NME8
NCBI Official Synonym Symbols:	CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2
NCBI Protein Information:	thioredoxin domain-containing protein 3
UniProt Protein Name:	Thioredoxin domain-containing protein 3
UniProt Synonym Protein Names:	NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2
Protein Family:	Thioredoxin domain-containing protein
UniProt Gene Name:	NME8
UniProt Entry Name:	TXND3_HUMAN