Cell Biology Antibodies 2
Anti-NMB Antibody (CAB12158)
(No reviews yet)
Write a Review
- SKU:
- CAB12158
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NMB Antibody |
| Antibody SKU: | CAB12158 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-121 of human NMB (NP_066563.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, PC-12, Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-121 of human NMB (NP_066563.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARR AGGA RMFG SLLL FALL AAGV APLS WDLP EPRS RASK IRVH SRGN LWAT GHFM GKKS LEPS SPSP LGTA PHTS LRDQ RLQL SHDL LGIL LLKK ALGV SLSR PAPQ IQYR RLLV QILQ K |
| Gene ID: | 4828 |
| Uniprot: | P08949 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa/16kDa |
| Observed MW: | 17kDa |
| Synonyms: | NMB |
| Background: | This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NMB: Stimulates smooth muscle contraction in a manner similar to that of bombesin. Belongs to the bombesin/neuromedin-B/ranatensin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q25.2 Cellular Component: extracellular region Molecular Function:hormone activity; protein binding Biological Process: cell-cell signaling; signal transduction |
| NCBI Summary: | This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P08949 |
| NCBI GenInfo Identifier: | 281185514 |
| NCBI Gene ID: | 4828 |
| NCBI Accession: | P08949.4 |
| UniProt Secondary Accession: | P08949,Q96A06, Q96HH5, |
| UniProt Related Accession: | P08949 |
| Molecular Weight: | 13kDa |
| NCBI Full Name: | Neuromedin-B |
| NCBI Synonym Full Names: | neuromedin B |
| NCBI Official Symbol: | NMB |
| NCBI Protein Information: | neuromedin-B |
| UniProt Protein Name: | Neuromedin-B |
| Protein Family: | Neuromedin |
| UniProt Gene Name: | NMB |
 | Western blot analysis of extracts of various cell lines, using NMB antibody (CAB12158) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
View AllClose
Related Products
