Immunology Antibodies 2
Anti-NLRX1 Antibody (CAB4976)
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- SKU:
- CAB4976
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NLRX1
- Synonyms:
- CLR11.3
- Synonyms:
- DLNB26
- Synonyms:
- NOD26
- Synonyms:
- NOD5
- Synonyms:
- NOD9
- Research Area:
- Immunology
Description
| Product Name: | NLRX1 Rabbit pAb |
| Product Code: | CAB4976 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NLRX1, CLR11.3, DLNB26, NOD26, NOD5, NOD9 |
| Applications: | WB, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 87-360 of human NLRX1 (NP_001269073.1). |
| Applications: | WB, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Mouse heart, Mouse kidney, Mouse liver, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 87-360 of human NLRX1 (NP_001269073.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AEWF SRLP REER QFGP TFAL DTVH VDPV IRES TPDE LLRP PAEL ALEH QPPQ AGLP PLAL SQLF NPDA CGRR VQTV VLYG TVGT GKST LVRK MVLD WCYG RLPA FELL IPFS CEDL SSLG PAPA SLCQ LVAQ RYTP LKEV LPLM AAAG SHLL FVLH GLEH LNLD FRLA GTGL CSDP EEPQ EPAA IIVN LLRK YMLP QASI LVTT RPSA IGRI PSKY VGRY GEIC GFSD TNLQ KLYF QLRL NQPY CGYA VGGS GVSA TPAQ RDHL VQML SRNL EG |
| Gene ID: | 79671 |
| Uniprot: | Q86UT6 |
| Cellular Location: | Mitochondrion outer membrane |
| Calculated MW: | 101kDa/107kDa |
| Observed MW: | 108kDa |
| UniProt Protein Function: | NLRX1: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Interacts with MAVS. Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji, and Jurkat cell lines. Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: mitochondrial outer membrane Molecular Function:protein binding; ATP binding Biological Process: viral reproduction; negative regulation of innate immune response; negative regulation of inflammatory response; negative regulation of interleukin-6 production; innate immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interferon type I production; negative regulation of interferon-beta production |
| NCBI Summary: | The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q86UT6 |
| NCBI GenInfo Identifier: | 74759406 |
| NCBI Gene ID: | 79671 |
| NCBI Accession: | Q86UT6.1 |
| UniProt Secondary Accession: | Q86UT6,Q7RTR3, Q96D51, Q9H724, A8K6Q1, B3KPK2, B3KTA2 |
| UniProt Related Accession: | Q86UT6 |
| Molecular Weight: | 975 |
| NCBI Full Name: | NLR family member X1 |
| NCBI Synonym Full Names: | NLR family member X1 |
| NCBI Official Symbol: | NLRX1 |
| NCBI Official Synonym Symbols: | NOD5; NOD9; NOD26; DLNB26; CLR11.3 |
| NCBI Protein Information: | NLR family member X1; NLR family, X1; NOD-like receptor X1; caterpiller protein 11.3; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain protein 26; nucleotid |
| UniProt Protein Name: | NLR family member X1 |
| UniProt Synonym Protein Names: | Caterpiller protein 11.3; CLR11.3; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9 |
| Protein Family: | NLR family |
| UniProt Gene Name: | NLRX1 |
| UniProt Entry Name: | NLRX1_HUMAN |
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