Cell Biology Antibodies 2
Anti-NLRP7 Antibody (CAB11627)
- SKU:
- CAB11627
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-NLRP7 Antibody |
Antibody SKU: | CAB11627 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_631915.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | HeLa, U-87MG, 293T, Jurkat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_631915.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | CRLT EASC KDLA AVLV VSKK LTHL CLAK NPIG DTGV KFLC EGLS YPDC KLQT LVLQ QCSI TKLG CRYL SEAL QEAC SLTN LDLS INQI ARGL WILC QALE NPNC NLKH LRLW SCSL MPFY CQHL GSAL LSNQ KLET LDLG QNHL WKSG IIKL FGVL RQRT GSLK ILRL KTYE TNLE IKKL LEEV KEKN PKLT IDCN ASGA T |
Gene ID: | 199713 |
Uniprot: | Q8WX94 |
Cellular Location: | |
Calculated MW: | 111kDa/114kDa/118kDa |
Observed MW: | 110kDa |
Synonyms: | NLRP7, CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3 |
Background: | This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 19q13.42 Disease: Hydatidiform Mole, Recurrent, 1 |
NCBI Summary: | This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WX94 |
NCBI GenInfo Identifier: | 24212128 |
NCBI Gene ID: | 199713 |
NCBI Accession: | Q8WX94.1 |
UniProt Secondary Accession: | Q8WX94,Q32MH8, Q7RTR1, E9PE16, |
UniProt Related Accession: | Q8WX94 |
Molecular Weight: | 112kDa |
NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 7 |
NCBI Synonym Full Names: | NLR family pyrin domain containing 7 |
NCBI Official Symbol: | NLRP7 |
NCBI Official Synonym Symbols: | HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4 |
NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 7 |
UniProt Synonym Protein Names: | Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3 |
Protein Family: | NACHT, LRR and PYD domains-containing protein |
UniProt Gene Name: | NLRP7 |
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