Cell Biology Antibodies 2

Anti-NLRP7 Antibody (CAB11627)

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SKU:
CAB11627
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NLRP7 Antibody
Antibody SKU:CAB11627
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_631915.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, U-87MG, 293T, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_631915.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CRLT EASC KDLA AVLV VSKK LTHL CLAK NPIG DTGV KFLC EGLS YPDC KLQT LVLQ QCSI TKLG CRYL SEAL QEAC SLTN LDLS INQI ARGL WILC QALE NPNC NLKH LRLW SCSL MPFY CQHL GSAL LSNQ KLET LDLG QNHL WKSG IIKL FGVL RQRT GSLK ILRL KTYE TNLE IKKL LEEV KEKN PKLT IDCN ASGA T
Gene ID:199713
Uniprot:Q8WX94
Cellular Location:
Calculated MW:111kDa/114kDa/118kDa
Observed MW:110kDa
Synonyms:NLRP7, CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3
Background:This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 19q13.42

Disease: Hydatidiform Mole, Recurrent, 1

NCBI Summary:This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WX94
NCBI GenInfo Identifier:24212128
NCBI Gene ID:199713
NCBI Accession:Q8WX94.1
UniProt Secondary Accession:Q8WX94,Q32MH8, Q7RTR1, E9PE16,
UniProt Related Accession:Q8WX94
Molecular Weight:112kDa
NCBI Full Name:NACHT, LRR and PYD domains-containing protein 7
NCBI Synonym Full Names:NLR family pyrin domain containing 7
NCBI Official Symbol:NLRP7  
NCBI Official Synonym Symbols:HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4  
NCBI Protein Information:NACHT, LRR and PYD domains-containing protein 7
UniProt Protein Name:NACHT, LRR and PYD domains-containing protein 7
UniProt Synonym Protein Names:Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3
Protein Family:NACHT, LRR and PYD domains-containing protein
UniProt Gene Name:NLRP7  
Anti-NLRP7 Antibody (CAB11627)Western blot analysis of extracts of various cell lines, using NLRP7 Antibody (CAB11627) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s.
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