Antibody Name:	Anti-NLRP6 Antibody
Antibody SKU:	CAB15628
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NLRP6 (NP_001263629.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse stomach, Mouse kidney, Rat kidney

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NLRP6 (NP_001263629.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RRLQ RLGL GSGT LLSV SEYK KKYR EHVL QLHA RVKE RNAR SVKI TKRF TKLL IAPE SAAP EEAM GPAE EPEP GRAR RSDT HTFN RLFR RDEE GRRP LTVV L
Gene ID:	171389
Uniprot:	P59044
Cellular Location:
Calculated MW:	99kDa
Observed MW:	99KDa

Synonyms:

NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5

Background:

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.
UniProt Protein Details:	Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 11p15 Molecular Function:vasopressin receptor activity Biological Process: regulation of inflammatory response
NCBI Summary:	The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
UniProt Code:	P59044
NCBI GenInfo Identifier:	259016285
NCBI Gene ID:	171389
NCBI Accession:	P59044.2
UniProt Secondary Accession:	P59044,A8K9F3, E9PJZ8,
UniProt Related Accession:	P59044
Molecular Weight:	98,681 Da
NCBI Full Name:	NACHT, LRR and PYD domains-containing protein 6
NCBI Synonym Full Names:	NLR family pyrin domain containing 6
NCBI Official Symbol:	NLRP6
NCBI Official Synonym Symbols:	AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
NCBI Protein Information:	NACHT, LRR and PYD domains-containing protein 6
UniProt Protein Name:	NACHT, LRR and PYD domains-containing protein 6
UniProt Synonym Protein Names:	Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5
Protein Family:	NACHT, LRR and PYD domains-containing protein
UniProt Gene Name:	NLRP6
UniProt Entry Name:	NLRP6_HUMAN

	Western blot analysis of extracts of 293T cells, using NLRP6 antibody (CAB15628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
	Western blot analysis of extracts of various cell lines, using NLRP6 antibody (CAB15628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.