Immunology Antibodies 2

Anti-NLRP10 Antibody (CAB15976)

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SKU:
CAB15976
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-NLRP10 Antibody
Antibody SKU:CAB15976
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NLRP10 (NP_789791.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, LO2, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NLRP10 (NP_789791.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAMA KARK PREA LLWA LSDL EEND FKKL KFYL RDMT LSEG QPPL ARGE LEGL IPVD LAEL LISK YGEK EAVK VVLK GLKV MNLL ELVD QLSH ICLH DYRE VYRE HVRC LEEW QEAG VNGR YNQV LLVA KPSS ESPE SLAC PFPE QELE SVTV EALF DSGE KPSL APSL VVLQ GSAG TGKT TLAR KMVL DWAT GTLY PGRF DYVF YVSC KEVV LLLE SKLE QLLF WCCG DNQA PVTE ILRQ PERL LFIL DGFD ELQR PFEE KLKK RGLS PKES LLHL LIRR HTLP TCSL LITT RPLA LRNL
Gene ID:338322
Uniprot:Q86W26
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:75kDa
Observed MW:75kDa
Synonyms:NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD
Background:Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
UniProt Protein Function:NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; extrinsic to plasma membrane

Biological Process: defense response to fungus; defense response to Gram-negative bacterium; positive regulation of T-helper 1 type immune response

NCBI Summary:Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q86W26
NCBI GenInfo Identifier:46396380
NCBI Gene ID:338322
NCBI Accession:Q86W26.1
UniProt Secondary Accession:Q86W26,Q2M3C4, Q6JGT0,
UniProt Related Accession:Q86W26
Molecular Weight:75,032 Da
NCBI Full Name:NACHT, LRR and PYD domains-containing protein 10
NCBI Synonym Full Names:NLR family pyrin domain containing 10
NCBI Official Symbol:NLRP10  
NCBI Official Synonym Symbols:NOD8; PAN5; PYNOD; NALP10; CLR11.1  
NCBI Protein Information:NACHT, LRR and PYD domains-containing protein 10
UniProt Protein Name:NACHT, LRR and PYD domains-containing protein 10
UniProt Synonym Protein Names:Nucleotide-binding oligomerization domain protein 8
Protein Family:NACHT, LRR and PYD domains-containing protein
UniProt Gene Name:NLRP10  
UniProt Entry Name:NAL10_HUMAN
Anti-NLRP10 Antibody (CAB15976)Western blot analysis of extracts of various cell lines, using NLRP10 antibody (CAB15976) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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