Immunology Antibodies 2

Anti-NLRC5 Antibody (CAB16710)

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SKU:
CAB16710
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-NLRC5 Antibody
Antibody SKU:CAB16710
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human NLRC5
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:mouse lung
Immunogen:Recombinant protein of human NLRC5
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84166
Uniprot:Q86WI3
Cellular Location:
Calculated MW:204kDa
Observed MW:202kDa
Synonyms:NLRC5, CLR16.1, NOD27, NOD4
Background:This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.
UniProt Protein Function:NLRC5: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Belongs to the NLRP family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:protein binding; ATP binding

Biological Process: regulation of kinase activity; inhibition of NF-kappaB transcription factor; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of MHC class I biosynthetic process; defense response to virus; negative regulation of interferon type I production

NCBI Summary:This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
UniProt Code:Q86WI3
NCBI GenInfo Identifier:350529351
NCBI Gene ID:84166
NCBI Accession:NP_115582
UniProt Secondary Accession:Q86WI3,Q6P4A6, Q86VM7, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7 B5MEF1, C9JMD8,
UniProt Related Accession:Q86WI3
Molecular Weight:170,417 Da
NCBI Full Name:protein NLRC5
NCBI Synonym Full Names:NLR family, CARD domain containing 5
NCBI Official Symbol:NLRC5  
NCBI Official Synonym Symbols:NOD4; NOD27; CLR16.1  
NCBI Protein Information:protein NLRC5
UniProt Protein Name:Protein NLRC5
UniProt Synonym Protein Names:Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4
UniProt Gene Name:NLRC5  
UniProt Entry Name:NLRC5_HUMAN
Anti-NLRC5 Antibody (CAB16710)Western blot analysis of extracts of mouse lung, using NLRC5 antibody (CAB16710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min.
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