Cell Biology Antibodies 3

Anti-NLN Antibody (CAB13112)

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SKU:
CAB13112
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NLN Antibody
Antibody SKU:CAB13112
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-260 of human NLN (NP_065777.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HeLa, A-549, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-260 of human NLN (NP_065777.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSYT VAGR NVLR WDLS PEQI KTRT EELI VQTK QVYD AVGM LGIE EVTY ENCL QALA DVEV KYIV ERTM LDFP QHVS SDKE VRAA STEA DKRL SRFD IEMS MRGD IFER IVHL QETC DLGK IKPE ARRY LEKS IKMG KRNG LHLP EQVQ NEIK SMKK RMSE LCID FNKN LNED DTFL VFSK AELG ALPD DFID SLEK TDDD KYKI TLKY PHYF PVMK KCCI PET
Gene ID:57486
Uniprot:Q9BYT8
Cellular Location:Cytoplasm, Mitochondrion intermembrane space
Calculated MW:80kDa
Observed MW:80kDa
Synonyms:NLN, AGTBP, EP24.16, MEP, MOP
Background:This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
UniProt Protein Function:NLN: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Belongs to the peptidase M3 family.
UniProt Protein Details:

Protein type:EC 3.4.24.16; Mitochondrial; Protease

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: plasma membrane; mitochondrial intermembrane space

Molecular Function:metalloendopeptidase activity; metal ion binding; peptide binding

Biological Process: proteolysis

NCBI Summary:This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
UniProt Code:Q9BYT8
NCBI GenInfo Identifier:14149738
NCBI Gene ID:57486
NCBI Accession:NP_065777.1
UniProt Secondary Accession:Q9BYT8,Q9ULJ4,
UniProt Related Accession:Q9BYT8
Molecular Weight:80,652 Da
NCBI Full Name:neurolysin, mitochondrial
NCBI Synonym Full Names:neurolysin (metallopeptidase M3 family)
NCBI Official Symbol:NLN  
NCBI Official Synonym Symbols:MEP; MOP; AGTBP; EP24.16  
NCBI Protein Information:neurolysin, mitochondrial; endopeptidase 24.16; microsomal endopeptidase; neurotensin endopeptidase; angiotensin binding protein; angiotensin-binding protein; mitochondrial oligopeptidase M
UniProt Protein Name:Neurolysin, mitochondrial
UniProt Synonym Protein Names:Angiotensin-binding protein; Microsomal endopeptidase; MEP; Mitochondrial oligopeptidase M; Neurotensin endopeptidase
Protein Family:Neurolysin
UniProt Gene Name:NLN  
UniProt Entry Name:NEUL_HUMAN
Anti-NLN Antibody (CAB13112)Western blot analysis of extracts of various cell lines, using NLN antibody (CAB13112) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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