Cell Biology Antibodies 11
Anti-NLGN4X Antibody (CAB7986)
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- SKU:
- CAB7986
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | NLGN4X Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7986 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 697-816 of human NLGN4X (NP_065793.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, Mouse brain, Mouse thymus, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 697-816 of human NLGN4X (NP_065793.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YYKK DKRR HETH RRPS PQRN TTND IAHI QNEE IMSL QMKQ LEHD HECE SLQA HDTL RLTC PPDY TLTL RRSP DDIP LMTP NTIT MIPN TLTG MQPL HTFN TFSG GQNS TNLP HGHS TTRV |
| Gene ID: | 57502 |
| Uniprot: | Q8N0W4 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 91kDa/94kDa |
| Observed MW: | 92kDa |
| Synonyms: | NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin-4, X-linked |
| Background: | This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NLGN4X: Putative neuronal cell surface protein involved in cell- cell-interactions. Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.33 Cellular Component: postsynaptic membrane; extracellular space; cell surface; integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; plasma membrane; excitatory synapse; synapse; cell junction Molecular Function:protein binding; protein homodimerization activity; neurexin binding; cell adhesion molecule binding; receptor activity; chloride ion binding Biological Process: neuron differentiation; regulation of synaptic transmission; organ growth; intercellular junction assembly and maintenance; metabolic process; adult behavior; synapse organization and biogenesis; cerebellum development; neuron adhesion; social behavior; learning Disease: Asperger Syndrome, X-linked, Susceptibility To, 2; Autism, Susceptibility To, X-linked 2 |
| NCBI Summary: | This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q8N0W4 |
| NCBI GenInfo Identifier: | 31076821 |
| NCBI Gene ID: | 57502 |
| NCBI Accession: | Q8N0W4.1 |
| UniProt Secondary Accession: | Q8N0W4,Q6UX10, Q9ULG0, |
| UniProt Related Accession: | Q8N0W4 |
| Molecular Weight: | 91,915 Da |
| NCBI Full Name: | Neuroligin-4, X-linked |
| NCBI Synonym Full Names: | neuroligin 4, X-linked |
| NCBI Official Symbol: | NLGN4X |
| NCBI Official Synonym Symbols: | HLNX; HNL4X; NLGN4; ASPGX2; AUTSX2 |
| NCBI Protein Information: | neuroligin-4, X-linked |
| UniProt Protein Name: | Neuroligin-4, X-linked |
| UniProt Synonym Protein Names: | HNLX |
| Protein Family: | Neuroligin |
| UniProt Gene Name: | NLGN4X |
| UniProt Entry Name: | NLGNX_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NLGN4X antibody (CAB7986) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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