Name: Anti-NLGN2 Antibody (CAB14289)
Brand: Cell Biology Antibodies 4
SKU: CAB14289
Availability: OutOfStock

Antibody Name:	Anti-NLGN2 Antibody
Antibody SKU:	CAB14289
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 15-180 of human NLGN2 (NP_065846.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 15-180 of human NLGN2 (NP_065846.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QRGG GGPG GGAP GGPG LGLG SLGE ERFP VVNT AYGR VRGV RREL NNEI LGPV VQFL GVPY ATPP LGAR RFQP PEAP ASWP GVRN ATTL PPAC PQNL HGAL PAIM LPVW FTDN LEAA ATYV QNQS EDCL YLNL YVPT EDGP LTKK RDEA TLNP PDTD IRDP GKKP VM
Gene ID:	57555
Uniprot:	Q8NFZ4
Cellular Location:	Cell junction, Cell membrane, Single-pass type I membrane protein, postsynaptic cell membrane, presynaptic cell membrane, synapse
Calculated MW:	90kDa
Observed MW:	91kDa

Synonyms:	NLGN2
Background:	This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

UniProt Protein Function:	NLGN2: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Belongs to the type-B carboxylesterase/lipase family.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: cell junction; cell surface; extracellular space; integral to plasma membrane; membrane; postsynaptic membrane; presynaptic membrane; synapse Molecular Function:cell adhesion molecule binding; neurexin binding; receptor activity Biological Process: cell-cell adhesion; intercellular junction maintenance; neurological control of breathing; neuromuscular process controlling balance; neuron adhesion; positive regulation of insulin secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; regulation of synaptic transmission; sensory perception of pain; synapse organization and biogenesis; synaptic vesicle endocytosis; synaptogenesis
NCBI Summary:	This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
UniProt Code:	Q8NFZ4
NCBI GenInfo Identifier:	31076824
NCBI Gene ID:	57555
NCBI Accession:	Q8NFZ4.1
UniProt Secondary Accession:	Q8NFZ4,Q9P2I1,
UniProt Related Accession:	Q8NFZ4
Molecular Weight:	90,820 Da
NCBI Full Name:	Neuroligin-2
NCBI Synonym Full Names:	neuroligin 2
NCBI Official Symbol:	NLGN2
NCBI Protein Information:	neuroligin-2
UniProt Protein Name:	Neuroligin-2
Protein Family:	Neuroligin
UniProt Gene Name:	NLGN2
UniProt Entry Name:	NLGN2_HUMAN

Western blot analysis of extracts of mouse heart, using NLGN2 antibody (CAB14289) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-NLGN2 Antibody (CAB14418)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)